Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
We identified rare coding variants associated with Alzheimer's disease in a three-stage case–control
study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-…
study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-…
A quasi-global precipitation time series for drought monitoring
Estimating precipitation variations in space and time is an important aspect of drought early
warning and environmental monitoring. An evolving drier-than-normal season must be …
warning and environmental monitoring. An evolving drier-than-normal season must be …
Food security under climate change
Our third Moore’s Law factor—cleverness—can be increased by replacing some of these vias
with vertical nanowire transistors (13)(see the figure). These vertical transistors can reach …
with vertical nanowire transistors (13)(see the figure). These vertical transistors can reach …
[PDF][PDF] Multiscale analysis of independent Alzheimer's cohorts finds disruption of molecular, genetic, and clinical networks by human herpesvirus
Investigators have long suspected that pathogenic microbes might contribute to the onset
and progression of Alzheimer's disease (AD) although definitive evidence has not been …
and progression of Alzheimer's disease (AD) although definitive evidence has not been …
[PDF][PDF] Isoforms of RNA-editing enzyme ADAR1 independently control nucleic acid sensor MDA5-driven autoimmunity and multi-organ development
Mutations in ADAR, which encodes the ADAR1 RNA-editing enzyme, cause Aicardi-Goutières
syndrome (AGS), a severe autoimmune disease associated with an aberrant type I …
syndrome (AGS), a severe autoimmune disease associated with an aberrant type I …
[PDF][PDF] Meta-analysis of the Alzheimer's disease human brain transcriptome and functional dissection in mouse models
We present a consensus atlas of the human brain transcriptome in Alzheimer's disease (AD),
based on meta-analysis of differential gene expression in 2,114 postmortem samples. We …
based on meta-analysis of differential gene expression in 2,114 postmortem samples. We …
[PDF][PDF] IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior
Anti-inflammatory strategies are proposed to have beneficial effects in Alzheimer's disease.
To explore how anti-inflammatory cytokine signaling affects Aβ pathology, we investigated …
To explore how anti-inflammatory cytokine signaling affects Aβ pathology, we investigated …
[HTML][HTML] The viral hypothesis: how herpesviruses may contribute to Alzheimer's disease
The hypothesis that infectious agents, particularly herpesviruses, contribute to Alzheimer’s
disease (AD) pathogenesis has been investigated for decades but has long engendered …
disease (AD) pathogenesis has been investigated for decades but has long engendered …
[HTML][HTML] Declining global per capita agricultural production and warming oceans threaten food security
Despite accelerating globalization, most people still eat food that is grown locally. Developing
countries with weak purchasing power tend to import as little food as possible from global …
countries with weak purchasing power tend to import as little food as possible from global …
Estrogen Dendrimer Conjugates that Preferentially Activate Extranuclear, Nongenomic Versus Genomic Pathways of Estrogen Action
WR Harrington, SH Kim, CC Funk… - Molecular …, 2006 - academic.oup.com
Estrogenic hormones are classically thought to exert their effects by binding to nuclear
estrogen receptors and altering target gene transcription, but estrogens can also have …
estrogen receptors and altering target gene transcription, but estrogens can also have …