Interleukin 7 (IL-7) stimulates the proliferation of B cell progenitors, thymocytes, and mature
T cells through an interaction with a high affinity receptor (IL-7R) belonging to the …

Embryonic stem (ES) cells are promising for cardiac repair’ but directing their differentiation
toward cardiomyocytes remains challenging. We investigated whether the heart guides ES …

… C57BL/6-derived ES cells (CB Ware, unpublished observations) were electroporated
with the p55-targeting construct and selected as described previously (35). Approximately 1/20 …

The retina is subject to degenerative conditions, leading to blindness. Although retinal
regeneration is robust in lower vertebrates, regeneration does not occur in the adult mammalian …

The low-affinity receptor for leukemia inhibitory factor (LIFR) * interacts with gp130 to induce
an intracellular signal cascade. The LIFR-gp130 heterodimer is implicated in the function of …

Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections, and comprise
nearly 8% of the human genome 1 . The most recently acquired human ERV is HERVK(HML…

Excitotoxicity, a form of neuronal injury in which excessive activation of glutamate receptors
results in cellular calcium overload 1, 2, has been implicated in the pathogenesis of …

The naïve pluripotent state has been shown in mice to lead to broad and more robust
developmental potential relative to primed mouse epiblast cells. The human naïve ES cell state …

Each unit of the D4Z4 macrosatellite repeat contains a retrotransposed gene encoding the
DUX4 double-homeobox transcription factor. Facioscapulohumeral dystrophy (FSHD) is …

For nearly a century developmental biologists have recognized that cells from embryos can
differ in their potential to differentiate into distinct cell types. Recently, it has been recognized …