The essential amino acid tryptophan is a constituent of proteins and is also a substrate for
two important biosynthetic pathways: the generation of neurotransmitter 5-hydroxytryptamine (…

… the biocatalytic toolbox concerns a broad spectrum of efficient C–C bond forming methods.
… Hydratases catalyze the cofactor-independent addition of water onto C═C bonds yielding …

… In Scheme 2a, the important features of an enzyme contributing to the different steps are
exemplified for an enzyme enabling a C–C bond formation, namely, the acylation of resorcinol. (…

The chemokine receptor 5 (CKR5) protein serves as a secondary receptor on CD4 + T
lymphocytes for certain strains of human immunodeficiency virus-type 1 (HIV-1). The CKR5 …

… are represented in the INTEGRAL Science Working Team (ISWT), a portion of the total
scientific observing time, the guaranteed time, will be used for their Core Programme (Winkler …

Coronavirus disease 2019 (COVID-19) is known to cause multi-organ dysfunction 1 , 2 – 3
during acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), …

African Americans have higher rates of kidney disease than European Americans. Here, we
show that, in African Americans, focal segmental glomerulosclerosis (FSGS) and …

We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old
hunter-gatherers from Luxembourg and Sweden. We analysed these and other …

… , using one diploid genome per population, for the same populations that we used in a–c. …
; (b) I will not post the data publicly; (c) I will make no attempt to connect the genetic data to …

Major histocompatibility complex (MHC) genes (HLA in humans) regulate the immune response
to foreign antigens. Molecular and serologic techniques were used to identify products …