[HTML][HTML] Antibiotics: past, present and future
… Merck purchased Cubist in 2015 for $9.5B but have since closed the discovery arm of Cubist…
Given their role as Guest Editor, Matt Hutchings, Andrew Truman, Barrie Wilkinson, had no …
Given their role as Guest Editor, Matt Hutchings, Andrew Truman, Barrie Wilkinson, had no …
Protein disulfide isomerase
B Wilkinson, HF Gilbert - Biochimica et biophysica acta (BBA)-proteins and …, 2004 - Elsevier
… b′ domain and that the b′ domain of PDI alone is sufficient for the binding of small peptides.
However, the b… It appears that the b′ domain of PDI acts as the principal binding site for …
However, the b… It appears that the b′ domain of PDI acts as the principal binding site for …
Drug discovery beyond the 'rule-of-five'
MQ Zhang, B Wilkinson - Current opinion in biotechnology, 2007 - Elsevier
Although a very useful guideline for orally bioavailable small-molecule drug design, the ‘rule-of-five’
(also known as ‘Lipinski's rule of drug-likeness’) has to some extent been …
(also known as ‘Lipinski's rule of drug-likeness’) has to some extent been …
[HTML][HTML] Phase 1–2 trial of a SARS-CoV-2 recombinant spike protein nanoparticle vaccine
…, L Fries, JD Lickliter, P Griffin, B Wilkinson… - New england journal …, 2020 - Mass Medical Soc
Background NVX-CoV2373 is a recombinant severe acute respiratory syndrome coronavirus
2 (rSARS-CoV-2) nanoparticle vaccine composed of trimeric full-length SARS-CoV-2 spike …
2 (rSARS-CoV-2) nanoparticle vaccine composed of trimeric full-length SARS-CoV-2 spike …
[HTML][HTML] ApoE promotes the proteolytic degradation of Aβ
Apolipoprotein E is associated with age-related risk for Alzheimer's disease and plays
critical roles in Aβ homeostasis. We report that ApoE plays a role in facilitating the proteolytic …
critical roles in Aβ homeostasis. We report that ApoE plays a role in facilitating the proteolytic …
Reliability and validity of the mini international neuropsychiatric interview for children and adolescents (MINI-KID)
…, KM Milo, SL Stock, B Wilkinson - The Journal of clinical …, 2010 - psychiatrist.com
… and showed that the SDS predicted C-GAS scores with reasonable accuracy (B = −0.58, F1
= 97, P = .… Rogers, Milo, and Wilkinson and Ms Bannon report no additional financial or other …
= 97, P = .… Rogers, Milo, and Wilkinson and Ms Bannon report no additional financial or other …
[HTML][HTML] Minimum information about a biosynthetic gene cluster
A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi
and plants are known to be encoded in biosynthetic gene clusters. Information about these …
and plants are known to be encoded in biosynthetic gene clusters. Information about these …
[HTML][HTML] Tofacitinib or adalimumab versus placebo in rheumatoid arthritis
…, JD Bradley, B Wilkinson - … England Journal of …, 2012 - Mass Medical Soc
Background Tofacitinib (CP-690,550) is a novel oral Janus kinase inhibitor that is being
investigated for the treatment of rheumatoid arthritis. Methods In this 12-month, phase 3 trial, 717 …
investigated for the treatment of rheumatoid arthritis. Methods In this 12-month, phase 3 trial, 717 …
'Someone to Watch over Me': surveillance, discipline and the Just-in-Time labour process
G Sewell, B Wilkinson - Postmodern Management Theory, 2019 - taylorfrancis.com
Theory and observations are used to argue that JIT/TQC regimes both create and demand
systems of surveillance which improve on those of previous factory regimes by instilling …
systems of surveillance which improve on those of previous factory regimes by instilling …
The effects of school-based writing-to-learn interventions on academic achievement: A meta-analysis
…, MM Hurley, B Wilkinson - Review of educational …, 2004 - journals.sagepub.com
Since the early 1970s, many educators have touted writing as a means of enhancing learning.
Several reasons have been suggested for this purported enhancement: that writing is a …
Several reasons have been suggested for this purported enhancement: that writing is a …