Abstract Systems biology has experienced dramatic growth in the number, size, and
complexity of computational models. To reproduce simulation results and reuse models, …

… (b) When a specific metabolic activity is defined for the protein, an association is made with
the corresponding reaction. (c) In case the molecular function is not specified, the assigned …

… 3a,b shows a time course for this model at high glucose concentrations (ie high relative
to the affinity of the HK block for glucose). Without feedback inhibition of HK, hexose …

A large proportion of the 6,000 genes present in the genome of Saccharomyces cerevisiae,
and of those sequenced in other organisms, encode proteins of unknown function. Many of …

This paper examines whether the in vivo behavior of yeast glycolysis can be understood in
terms of the in vitro kinetic properties of the constituent enzymes. In nongrowing, anaerobic, …

… (B) Use of efficient and inefficient pathways at different growth rates (or, equivalently, at
different substrate concentrations) as a fraction of the total flux, which equals the flux through …

… b, Both, GitHub and GitLab support a branching strategy, which model builders could use
to curate different parts of the model simultaneously or to invite external experts to improve …

A genome-scale metabolic model of the lactic acid bacterium Lactobacillus plantarum WCFS1
was constructed based on genomic content and experimental data. The complete model …

… (B) Fluorescence microscopy shows that distinct metabolic states can be visualized using
pH i readouts. (C) Flow cytometry measurements based on pHluorin signals reveal the …

… (B) L. lactis M1gfp population growth rate expressed by the change in OD of a culture—ie, …
samples (of identical experiments to those in A and B), also decreases with the increase of the …