Ligands of the transforming growth factor-β (TGFβ) superfamily of growth factors initiate signal
transduction through a bewildering complexity of ligand–receptor interactions. Signalling …

Here, we report that genome editing by CRISPR–Cas9 induces a p53-mediated DNA
damage response and cell cycle arrest in immortalized human retinal pigment epithelial cells, …

During cell division, transcription factors (TFs) are removed from chromatin twice, during
DNA synthesis and during condensation of chromosomes. How TFs can efficiently find their …

TGF-β-induced Smad signal transduction from the membrane into the nucleus is not linear
and unidirectional, but rather a dynamic network that couples Smad phosphorylation and …

Upon transforming growth factor β (TGF-β) stimulation, Smads accumulate in the nucleus,
where they regulate gene expression. Using fluorescence perturbation experiments on Smad2 …

Transforming growth factor β (TGF-β) signalling leads to phosphorylation and activation of
receptor-regulated Smad2 and Smad3, which form complexes with Smad4 and accumulate in …

… To understand how specific these effects were for this particular B subunit, we investigated
the … We thus conclude that these two regulatory B subunits have distinct functions in the early …

Understanding the complex dynamics of growth factor signaling requires both mechanistic
and kinetic information. Although signaling dynamics have been studied for pathways …

Factor-inhibiting hypoxia-inducible factor (FIH) catalyzes the β-hydroxylation of an asparagine
residue in the C-terminal transcriptional activation domain of the hypoxia inducible factor (…

The catecholamine‐mediated modulation of the cytokine network has primarily been demonstrated
for leukocytes. Whereas catecholamines decrease the LPS‐induced production of IL‐…