Measuring epistasis in fitness landscapes: The correlation of fitness effects of mutations

L Ferretti, B Schmiegelt, D Weinreich… - Journal of theoretical …, 2016 - Elsevier
… (b) γ is the pairwise correlation in fitness effect of mutation between neighbor … b) Types
of epistasis, possible values of γ and examples of the corresponding fitness graphs. In (b

Universality classes of interaction structures for NK fitness landscapes

S Hwang, B Schmiegelt, L Ferretti, J Krug - Journal of Statistical Physics, 2018 - Springer
… We show in Appendix B that the correspondence between the AN model with negative
gamma distribution and the BN model can be extended to arbitrary k by setting the shape …

Evolutionary accessibility of modular fitness landscapes

B Schmiegelt, J Krug - Journal of Statistical Physics, 2014 - Springer
A fitness landscape is a mapping from the space of genetic sequences, which is modeled
here as a binary hypercube of dimension L, to the real numbers. We consider random models …

[HTML][HTML] Accessibility percolation on Cartesian power graphs

B Schmiegelt, J Krug - Journal of Mathematical Biology, 2023 - Springer
A fitness landscape is a mapping from a space of discrete genotypes to the real numbers. A
path in a fitness landscape is a sequence of genotypes connected by single mutational steps…

Epistasis and constraints in fitness landscapes

L Ferretti, D Weinreich, B Schmiegelt… - arXiv preprint arXiv …, 2015 - arxiv.org
Genotypic fitness landscapes are constructed by assessing the fitness of all possible
combinations of a given number of mutations. In the last years, several experimental fitness …

Caffeine-mediated enhancement of glucocorticoid receptor activity in human osteoblastic cells

M Föcking, D Schmiegelt, T Trapp - Biochemical and biophysical research …, 2005 - Elsevier
Caffeine-containing beverage consumption has been reported to be associated with an
increased risk for osteoporosis. Since the glucocorticoid receptor (GR) is a major factor in the …

Continuous queries on trajectories of moving objects

P Schmiegelt, B Seeger, A Behrend… - Proceedings of the 16th …, 2012 - dl.acm.org
… As can be seen in figure 1(b), the communication costs are minimized using our trajectory …
in combination with the popular B-Tree. In general, these kinds of adapted B-trees can handle …

Period index: A learned 2d hash index for range and duration queries

A Behrend, A Dignös, J Gamper, P Schmiegelt… - Proceedings of the 16th …, 2019 - dl.acm.org
… cell on level 1 of the bucket b[1], and it contains a pointer to the second cell 12 at the same
level. Cell[1] 12 of bucket b[1] contains a pointer to the first cell of bucket b[2] on the same level…

A concurrently updatable index structure for predicted paths of moving objects

P Schmiegelt, A Behrend, B Seeger, W Koch - Data & Knowledge …, 2014 - Elsevier
… Space filling curves are used by the authors of [23], [24] for their index structures in combination
with the popular B-tree. In general, these kinds of adapted B-trees can handle updates …

Querying the future of spatio-temporal objects

P Schmiegelt, B Seeger - Proceedings of the 18th SIGSPATIAL …, 2010 - dl.acm.org
Since navigation systems and tracking devices are becoming ubiquitous in our daily life, the
development of efficient methods for processing massive sets of mobile objects are of …