Measuring epistasis in fitness landscapes: The correlation of fitness effects of mutations
L Ferretti, B Schmiegelt, D Weinreich… - Journal of theoretical …, 2016 - Elsevier
… (b) γ is the pairwise correlation in fitness effect of mutation between neighbor … b) Types
of epistasis, possible values of γ and examples of the corresponding fitness graphs. In (b…
of epistasis, possible values of γ and examples of the corresponding fitness graphs. In (b…
Universality classes of interaction structures for NK fitness landscapes
… We show in Appendix B that the correspondence between the AN model with negative
gamma distribution and the BN model can be extended to arbitrary k by setting the shape …
gamma distribution and the BN model can be extended to arbitrary k by setting the shape …
Evolutionary accessibility of modular fitness landscapes
B Schmiegelt, J Krug - Journal of Statistical Physics, 2014 - Springer
A fitness landscape is a mapping from the space of genetic sequences, which is modeled
here as a binary hypercube of dimension L, to the real numbers. We consider random models …
here as a binary hypercube of dimension L, to the real numbers. We consider random models …
[HTML][HTML] Accessibility percolation on Cartesian power graphs
B Schmiegelt, J Krug - Journal of Mathematical Biology, 2023 - Springer
A fitness landscape is a mapping from a space of discrete genotypes to the real numbers. A
path in a fitness landscape is a sequence of genotypes connected by single mutational steps…
path in a fitness landscape is a sequence of genotypes connected by single mutational steps…
Epistasis and constraints in fitness landscapes
L Ferretti, D Weinreich, B Schmiegelt… - arXiv preprint arXiv …, 2015 - arxiv.org
Genotypic fitness landscapes are constructed by assessing the fitness of all possible
combinations of a given number of mutations. In the last years, several experimental fitness …
combinations of a given number of mutations. In the last years, several experimental fitness …
Caffeine-mediated enhancement of glucocorticoid receptor activity in human osteoblastic cells
M Föcking, D Schmiegelt, T Trapp - Biochemical and biophysical research …, 2005 - Elsevier
Caffeine-containing beverage consumption has been reported to be associated with an
increased risk for osteoporosis. Since the glucocorticoid receptor (GR) is a major factor in the …
increased risk for osteoporosis. Since the glucocorticoid receptor (GR) is a major factor in the …
Continuous queries on trajectories of moving objects
… As can be seen in figure 1(b), the communication costs are minimized using our trajectory …
in combination with the popular B-Tree. In general, these kinds of adapted B-trees can handle …
in combination with the popular B-Tree. In general, these kinds of adapted B-trees can handle …
Period index: A learned 2d hash index for range and duration queries
… cell on level 1 of the bucket b[1], and it contains a pointer to the second cell 12 at the same
level. Cell[1] 12 of bucket b[1] contains a pointer to the first cell of bucket b[2] on the same level…
level. Cell[1] 12 of bucket b[1] contains a pointer to the first cell of bucket b[2] on the same level…
A concurrently updatable index structure for predicted paths of moving objects
… Space filling curves are used by the authors of [23], [24] for their index structures in combination
with the popular B-tree. In general, these kinds of adapted B-trees can handle updates …
with the popular B-tree. In general, these kinds of adapted B-trees can handle updates …
Querying the future of spatio-temporal objects
P Schmiegelt, B Seeger - Proceedings of the 18th SIGSPATIAL …, 2010 - dl.acm.org
Since navigation systems and tracking devices are becoming ubiquitous in our daily life, the
development of efficient methods for processing massive sets of mobile objects are of …
development of efficient methods for processing massive sets of mobile objects are of …