Oral–facial–digital syndromes (OFDS) gather rare genetic disorders characterised by facial,
oral and digital abnormalities associated with a wide range of additional features (polycystic …

… (B) Default neural induction in dissociated animal caps (AC) cells. (C) Western blot assay
using anti-C-terminal-phospho-Smad1 (C-ter-P-Smad1) antibody in animal cap cells …

… b, Adding increasing amounts of CTGF inhibits AP induced by 2.5 nM of BMP4. We
estimate that CTGF can block BMP4 activity with an IC 50 of about 12 nM. Error bars represent …

We report here the discovery and characterization of a gene, ELABELA (ELA), encoding a
conserved hormone of 32 amino acids. Present in human embryonic stem cells, ELA is …

… (B–L) Major clinical symptoms of MSPC and FKLC. (B) Indurated ulcer with overlying crust
and surrounding hyperkeratosis on the heel. (C) Firm, scaly nodule on the outer part of the …

Approximately 1.1 billion people currently live in countries where consanguineous
marriages are customary, and among them one in every three marriages is between cousins. …

… S1, A and B), despite similar or even higher levels of expression. The ability of HRV14-3Cpro
to activate human NLRP1 was entirely dependent on its enzymatic activity, because …

… (b) Scl expression was abrogated in Pycr1 morphants suffering anemia (Supplementary
Videos 1 and 2). (c) Parabiosis performed at stage 22 between a Pycr1-depleted (MO) tadpole (…

Preeclampsia (PE) is a gestational hypertensive syndrome affecting between 5 and 8% of all
pregnancies. Although PE is the leading cause of fetal and maternal morbidity and mortality…

Embryos have the ability to self-regulate and regenerate normal structures after being sectioned
in half. How is such a morphogenetic field established? We discovered that quadruple …