… (B) Identification of covarying residues in histidine kinases and response regulators. Cognate
operon pairs of histidine kinases and response regulators were concatenated and aligned. …

… The canonical two-component signal transduction system is shown in Figure 1B. A
histidine kinase, often in response to receipt of a signal or stimulus, autophosphorylates on a …

… 6) for each strain are quantified in b with representative images shown in c. Error bars
represent the mean ± sd from three independent sets of 150 cells. d, Levels of CtrAP per cell in …

… B. Ovals represent the set of protein B variants that are bound by protein A, and Xs indicate
particular protein B variants. Note that the intermediate state is a non-functional interaction. (…

Orthologous proteins often harbor numerous substitutions, but whether these differences
result from neutral or adaptive processes is usually unclear. To tackle this challenge, we …

… When grown in the absence of vanillate to deplete DivK and at 37 C to inactivate DivL, this
strain accumulated multiple chromosomes as with the divLts strain (Figure 1B), suggesting …

… (B) The histidine kinases EnvZ and CpxA were autophosphorylated and examined for
phosphotransfer to the response regulators indicated. The mutations in OmpR(MI-CpxR) and …

Cells must coordinate DNA replication with cell division, especially during episodes of DNA
damage. The paradigm for cell division control following DNA damage in bacteria involves …

… B. CC1114 amino acid sequence was aligned against the phosphotransferase domain of
ArcB (gi48994928, fragment 655–778 aa), the P1 domain of CheA (gi16129840, fragment 1–…

… , with no protein detected after 1 hr (Figure 2B). We then examined the morphology and …
(B) Western blot analysis showing SciP levels postshift to glucose or maintained in xylose at …