Antisense therapy for cancer

ME Gleave, BP Monia - Nature Reviews Cancer, 2005 - nature.com
… of 5′-cap formation and of polyadenylation (b), and inhibition of ribosomal readthrough (c). …
as substrates for RNase H enzymes (shown in red; b,d) that cleave the RNA in DNA–RNA …

Therapeutic potential for microRNAs

CC Esau, BP Monia - Advanced drug delivery reviews, 2007 - Elsevier
… Overexpression of this cluster, which contains six miRNAs from three families, substantially
accelerated B-cell lymphoma development in a c-Myc transgenic mouse model [119]. …

[HTML][HTML] miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

…, BA Lollo, S Freier, CF Bennett, S Bhanot, BP Monia - Cell metabolism, 2006 - cell.com
… AML12 cells led to a decrease in mRNA level for the same five targets that were upregulated
by ASO treatment of primary hepatocytes, while MINK1 was again unaffected (Figure 1B). …

[PDF][PDF] Second-generation antisense oligonucleotides: structure—activity relationships and the design of improved signal-transduction inhibitors

…, D Fabbro, NM Dean, T Geiger, BP Monia… - Biochemical Society …, 1996 - researchgate.net
The concept of inhibition of protein expression by antisense oligonucleotides has emerged
over the last few years as an important and potentially very powerful alternative to traditional …

[HTML][HTML] Inotersen treatment for patients with hereditary transthyretin amyloidosis

…, AM Shah, SD Solomon, BP Monia… - … England Journal of …, 2018 - Mass Medical Soc
Background Hereditary transthyretin amyloidosis is caused by pathogenic single-nucleotide
variants in the gene encoding transthyretin (TTR) that induce transthyretin misfolding and …

[HTML][HTML] PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients

…, M Tan, FJ Esteva, AA Sahin, KS Klos, P Li, BP Monia… - Cancer cell, 2004 - cell.com
B: PI3K assay after 2 μg/ml of trastuzumab treatment of SKBr3 cells for the indicated time.
Lysates were immunoprecipitated with the PY20 antibody followed by incubation in kinase …

[PDF][PDF] Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis

…, J Huang, XX Yu, SK Pandey, S Bhanot, BP Monia… - …, 2007 - Wiley Online Library
… (B) Serum ALT was measured after 4 and 8 weeks of treatment. Mean … (B) Expression of
Cyp2E1 and catalase was evaluated by immunoblot analysis of livers from 3 mice/group after 4 (…

Evaluation of 2 '-modified oligonucleotides containing 2 '-deoxy gaps as antisense inhibitors of gene expression

BP Monia, EA Lesnik, C Gonzalez, WF Lima… - Journal of Biological …, 1993 - ASBMB
B, fraction of hairpin target shifted uersus concentration of antisense oligonucleotide for
the seven oligonucleotides described in Fig. 0, deoxy number = 17; 0, deoxy number = 9; A, …

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

…, RA McKay, S Bhanot, BP Monia… - Proceedings of the …, 2002 - National Acad Sciences
… These changes in protein expression correlated with increased insulin-stimulated protein
kinase B phosphorylation. The expression of liver gluconeogenic enzymes, …

[HTML][HTML] Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2

…, XX Yu, JG Geisler, S Bhanot, BP Monia… - The Journal of …, 2006 - Am Soc Clin Investig
Hepatic steatosis is a core feature of the metabolic syndrome and type 2 diabetes and leads
to hepatic insulin resistance. Malonyl-CoA, generated by acetyl-CoA carboxylases 1 and 2 (…