Studies of long-lived individuals have revealed few genetic mechanisms for protection
against age-associated disease. Therefore, we pursued genome sequencing of a related …

The gut microbiome is a malleable microbial community that can remodel in response to
various factors, including diet, and contribute to the development of several chronic diseases, …

Introduction: Data suggest dietary modification can improve clinical responses in
inflammatory bowel disease (IBD). The goal of this study was to determine the efficacy of an …

Estrogen- and microRNA-mediated gene regulation play a crucial role in breast cancer
biology. However, a functional link between the two major players remains unclear. This study …

Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely
used to reduce disease progression, treatment fails in ∼one-third of patients. No biomarker …

We developed a smartphone application, MyGeneRank, to conduct a prospective observational
cohort study (NCT03277365) involving the automated generation, communication, and …

Germline variants in tumor suppressor genes (TSGs) can result in RNA mis-splicing and
predisposition to cancer. However, identification of variants that impact splicing remains a …

Background Synthetic genomic approaches offer unique opportunities to use powerful yeast
and Escherichia coli genetic systems to assemble and modify chromosome-sized …

… B respectively. If α and β are the fraction of samples of A classified as B and the fraction of
samples of B … number of samples, the similarity S(A,B) between A and B can be defined as - …

… 2a, b (intronic variants classified as B/LB prior to this study that had no aberrant RNA were
excluded). Splicing variants were defined as those with a deleterious impact by in silico …