[PDF][PDF] The library of integrated network-based cellular signatures NIH program: system-level cataloging of human cells response to perturbations
…, D Sareen, L Ornelas, M Banuelos, B Mandefro… - Cell systems, 2018 - cell.com
The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common
Fund program that catalogs how human cells globally respond to chemical, genetic, and …
Fund program that catalogs how human cells globally respond to chemical, genetic, and …
[HTML][HTML] Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells
U Ben-David, G Arad, U Weissbein, B Mandefro… - Nature …, 2014 - nature.com
Human pluripotent stem cells (hPSCs) tend to acquire genomic aberrations in culture, the
most common of which is trisomy of chromosome 12. Here we dissect the cellular and …
most common of which is trisomy of chromosome 12. Here we dissect the cellular and …
[PDF][PDF] Human iPSC-derived endothelial cells and microengineered organ-chip enhance neuronal development
…, A Laperle, A Meyer, M Godoy, PS Kay, B Mandefro… - Stem cell reports, 2018 - cell.com
… (B) Single population histogram of Chips seeded only with non-GFP BMECs (black) or
GFP-spMNs (green) that defined negative and positive fractions, respectively. Number of events is …
GFP-spMNs (green) that defined negative and positive fractions, respectively. Number of events is …
HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity
…, A Sahabian, L Lenaeus, B Mandefro… - Human molecular …, 2015 - academic.oup.com
Huntington's disease (HD) is a fatal neurodegenerative disease, caused by expansion of
polyglutamine repeats in the Huntingtin gene, with longer expansions leading to earlier ages of …
polyglutamine repeats in the Huntingtin gene, with longer expansions leading to earlier ages of …
Gene activation of SMN by selective disruption of lncRNA-mediated recruitment of PRC2 for the treatment of spinal muscular atrophy
…, HE Johansson, B Mandefro… - Proceedings of the …, 2017 - National Acad Sciences
Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by progressive
motor neuron loss and caused by mutations in SMN1 (Survival Motor Neuron 1). The …
motor neuron loss and caused by mutations in SMN1 (Survival Motor Neuron 1). The …
Human embryonic stem cells as models for aneuploid chromosomal syndromes
JC Biancotti, K Narwani, N Buehler, B Mandefro… - Stem …, 2010 - academic.oup.com
Syndromes caused by chromosomal aneuploidies are widely recognized genetic disorders
in humans and often lead to spontaneous miscarriage. Preimplantation genetic screening is …
in humans and often lead to spontaneous miscarriage. Preimplantation genetic screening is …
Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines
…, L Ornelas, N Yeager, B Mandefro… - Stem cells …, 2014 - academic.oup.com
… These lines are established by infecting resting peripheral B lymphocytes isolated from
simple blood draws with Epstein Barr virus (EBV) to give rise to actively proliferating LCLs [9]. …
simple blood draws with Epstein Barr virus (EBV) to give rise to actively proliferating LCLs [9]. …
[HTML][HTML] Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines
…, E Galvez, D Perez, I Meepe, S Lei, B Mandefro… - Nature …, 2022 - nature.com
Answer ALS is a biological and clinical resource of patient-derived, induced pluripotent
stem (iPS) cell lines, multi-omic data derived from iPS neurons and longitudinal clinical and …
stem (iPS) cell lines, multi-omic data derived from iPS neurons and longitudinal clinical and …
[HTML][HTML] Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development
Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized
by degeneration of spinal motor neurons, and caused by reduced levels of the SMN …
by degeneration of spinal motor neurons, and caused by reduced levels of the SMN …
[PDF][PDF] An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients
Neurodegenerative diseases are challenging for systems biology because of the lack of
reliable animal models or patient samples at early disease stages. Induced pluripotent stem …
reliable animal models or patient samples at early disease stages. Induced pluripotent stem …