The quantification of differences between two or more physiological states of a biological
system is among the most important but also most challenging technical tasks in proteomics. In …

Mass-spectrometry-based proteomics is continuing to make major contributions to the
discovery of fundamental biological processes and, more recently, has also developed into an …

The evolution of mass spectrometry–based proteomic technologies has advanced our
understanding of the complex and dynamic nature of proteomes while concurrently revealing that …

Most cellular processes are carried out by multiprotein complexes. The identification and
analysis of their components provides insight into how the ensemble of expressed proteins (…

Protein complexes are key molecular entities that integrate multiple gene products to
perform cellular functions. Here we report the first genome-wide screen for complexes in an …

… b, Elastic net analysis for the identification of drug sensitivity (positive-effect-size) or resistance
(negative-effect-size) markers against the … Instead, we used the criteria shown in a and b. …

Signal transduction pathways are modular composites of functionally interdependent sets of
proteins that act in a coordinated fashion to transform environmental information into a …

We describe a chemical proteomics approach to profile the interaction of small molecules
with hundreds of endogenously expressed protein kinases and purine-binding proteins. This …

INTRODUCTION Understanding drug mechanism poses the daunting challenge of determining
the affinity of the drug for all potential targets. Drug target engagement can be assessed …

… Two mixtures, A and B, were constructed. The concentration of each analyte in mixtures A
and B is provided in parenthesis as ([A],[B]). It is evident that some peptides are much more …