Background Ongoing innovation in phylogenetics and evolutionary biology has been
accompanied by a proliferation of software tools, data formats, analytical techniques and web …

Cascades of phosphorylation between protein kinases comprise a core mechanism in the
integration and propagation of intracellular signals. Although we have accumulated a wealth …

Persister and viable but non-culturable (VBNC) cells are two clonal subpopulations that can
survive multidrug exposure via a plethora of putative molecular mechanisms. Here, we …

Polyphenisms—the expression of discrete phenotypic morphs in response to environmental
variation—are examples of phenotypic plasticity that may potentially be adaptive in the face …

… Rod bipolar cells are the source of the b-wave in the dark-adapted retina [9–12]. The b-wave …
However, the b-wave is not the most sensitive to dim stimuli. Rather, the scotopic threshold …

The comparative DNA binding properties and cytotoxic activity of CDPI n methyl esters (n = 1–5)
vs. PDE-I n methyl esters (n = 1–3) are detailed in studies which provide experimental …

… B over 1 min, 6–15% B over 58 min, 15–32%B over 58 min, 32–40%B over 5 min, 40–90%B
over 1 min, held at 90%B for 6 min and then reduced to 1%B over 1 min) with a flow rate of …

… We found that, indeed, B-raf has specificity toward MAP2K1’s activating sites while MAPK3
is specific toward the inhibitory sites (Figure 3E). We then calculated a DCG on the signed …

… proteins, 436 were annotated with at least one gene ontology (GO) term, which we used
to detect biological functions enriched within individual phosphosite clusters (Figure 2B; see …

We performed genome-wide chemical mutagenesis of C57BL/6J mice using N-ethyl-N-nitrosourea
(ENU). Electroretinographic screening of the third generation offspring revealed two …