All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

The introduction of the operating microscope, the principle of early surgery, specialized
intensive care units, the calcium antagonist nimodipine, the sophisticated pre- and postoperative …

Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …

Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain
stem. It is the most common malignant brain tumour in children, and shows tremendous …

Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose
debilitating effects on the developing child, and highlight the need for molecularly targeted …

Pilocytic astrocytoma, the most common childhood brain tumor 1 , is typically associated with
mitogen-activated protein kinase (MAPK) pathway alterations 2 . Surgically inaccessible …

Background ECCO essential requirements for quality cancer care (ERQCC) are checklists
and explanations of organisation and actions that are necessary to give high-quality care to …

… in sample EOPC-05, also harboring a large (55 Mb) deletion removing the other PTEN
allele, with our transcriptome data showing a pronounced PTEN downregulation (Figure 2B). …

The identification of gene fusions from RNA sequencing data is a routine task in cancer
research and precision oncology. However, despite the availability of many computational tools, …

Regulation touches upon areas of vital importance to our lives and the economy, but it is still
very much a'grey area'of criminal law and social control, subject to very little academic …