High-throughput single-cell RNA sequencing has transformed our understanding of complex
cell populations, but it does not provide phenotypic information such as cell-surface protein …

… b Representative scatter plot showing raw counts for HTO A and HTO B across all cell
barcodes. Both axes are clipped at 99.9% quantiles to exclude visual outliers. c Heatmap of …

… b–d constitute a reanalysis of previously published data 18 . b, Histogram of samples
detected as a function of the maximum VAF in stage IV (left) and stage I (right) cancer. Maximum …

TRK fusions are found in a variety of cancer types, lead to oncogenic addiction, and strongly
predict tumor-agnostic efficacy of TRK inhibition 1 , 2 , 3 , 4 , 5 , 6 , 7 – 8 . With the recent …

Elucidating the molecular details of how chromatin-associated factors deposit, remove and
recognize histone post-translational modification (PTM) signatures remains a daunting task in …

Most retroviruses require translational recoding of a viral messenger RNA stop codon to
maintain a precise ratio of structural (Gag) and enzymatic (Pol) proteins during virus assembly 1 …

Importance The combination of erlotinib and bevacizumab as initial treatment of epidermal
growth factor receptor (EGFR[OMIM131550])–mutant lung cancers improves progression-free …

Purpose: Invasive mucinous adenocarcinoma (IMA) is a unique subtype of lung adenocarcinoma,
characterized genomically by frequent KRAS mutations or specific gene fusions, most …

Background Lineage plasticity, the ability to transdifferentiate among distinct phenotypic
identities, facilitates therapeutic resistance in cancer. In lung adenocarcinomas (LUADs), this …

… (B) Development of FGFR2 acquired resistance mutations and re-emergence of FGFR2-…
(B) Clustering of acquired resistance fibroblast growth factor receptor (FGFR) 2 mutations in the …