DNA methylation occurs in bacteria, fungi, plants and animals, however its role varies
widely among different organisms. Even within animal genomes, methylation patterns vary …

Through decades of research it has been established that some chromatin-modifying proteins
can repress transcription, and thus are generally termed ‘repressors’. Although classic …

Mammalian DNA is methylated at many CpG dinucleotides. The biological consequences of
methylation are mediated by a family of methyl-CpG binding proteins 1, 2, 3, 4. The best …

… b, Repression of a methylated reporter construct containing the pGL2 promoter relative to
the same reporter unmethylated, is only slightly less efficient in Mecp2 −/y cells than in wild-…

We describe the construction, evaluation and application of cDNA libraries from unfertilized
oocytes, and single 2-cell, 4-cell, 7-cell and blastocyst stage embryos. The corresponding …

… in (B) and (C), as well as methylationsensitive restriction enzyme sites discussed in the text.
… The use of the parental mouse cell line tsA1 S9az31 b (for all hybrids except AHA- laB1) …

… (A) Immediately following fertilisation, sperm complexed with protamine acquires histones
from the maternal cytoplasm (B). These histones are already acetylated when newly acquired …

… Kaji and B. Hendrich, unpublished). Analysis of a handful of genes misexpressed in Mbd3
null ES cells identified at least 11 genes that are misregulated in pre-implantation Mbd3 null …

… While chromosome structure varies markedly from cell to cell, we find that regions
belonging to the A or B compartments always cluster together and A segregates from …

… a, b and d are fluorescence scans of denaturing 15% … b, Full-length MBD4 incubated under
conditions that favour the … Solid circles in b and c indicate interstrand base mismatches. …