… b and error bars indicate SE for r b . Right, correlation between cell type counts (mean over
the subset of samples from the 1M-scBloodNL cohort; N = 112) and r b … SE for r b and sem for …

Identifying the downstream effects of disease-associated SNPs is challenging. To help
overcome this problem, we performed expression quantitative trait locus (eQTL) meta-analysis in …

… (B) This genetic marker shows association with expression of 17 genes on different chromosomes
(trans-eQTLs) after 24 hours of LPS stimulation, forming a gene network (C) consistent …

… We found that the best model for association included the HLA class I alleles HLA-B*08:01
and HLA-B*18:01, the class II alleles HLA-DQB1*02:01, HLA-DRB3*02:00 and HLA-DQA*01:…

… our analysis of primary monocytes and B cells, we observed several eQTLs … in B cells and
monocytes. We identified 197 eSNPs in 35 genes with significant 'directional eQTL' activity in B …

… allele for rs7216389 and were mostly expressed in B cells and natural killer cells 31 (… B-cell
proliferation 31,32 , suggesting that a decrease of IKZF3 leads to an increased number of B …

… B cells and activation of autoreactive B cells We then investigated at high resolution how B
cell … overall frequency and number of B cells, predominantly naive B cells, but an increase in …

… 3 ) and became more significant as an interaction with deconvoluted B cell proportions 22
(P = 1.5 × 10 −7 ; Methods), consistent with B cell specificity (Supplementary Fig. 20), although …

… and function of myeloid and B-lymphoid cells 43,44 . In … B-lymphoid lineage by progressively
partitioning into CD14 + monocytes and macrophages, CD15 + neutrophils and CD19 + B …

… minor allele of rs2223286, a SNP intronic to SELL that disrupts a consensus motif for FOS
and is located in a c-Fos ChIP-seq peak is associated with increased expression of SELL in B-…