User profiles for B. Engelhardt

Britta Engelhardt

- Verified email at tki.unibe.ch - Cited by 37113

Barbara Engelhardt

- Verified email at stanford.edu - Cited by 15221

The anatomical and cellular basis of immune surveillance in the central nervous system

RM Ransohoff, B Engelhardt - Nature Reviews Immunology, 2012 - nature.com
b | Arachnoid granulations in relation to the subarachnoid space and brain parenchyma. c
| Subpial vasculature in relation to subarachnoid space and brain parenchyma, indicating the …

The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction

B Engelhardt, L Sorokin - Seminars in immunopathology, 2009 - Springer
b Electronmicroscopy showing the endothelial cell and the parenchymal BMs at the level
of smaller blood vessels. Insert shows higher magnification image of boxed area …

The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms

B Engelhardt, RM Ransohoff - Trends in immunology, 2005 - cell.com
This review addresses current knowledge of the molecular trafficking signals involved in the
migration of circulating leukocytes across the highly specialized blood–central nervous …

A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

…, WB Kiosses, E Dejana, DA Schultz, B Engelhardt… - Nature, 2005 - nature.com
Shear stress is a fundamental determinant of vascular homeostasis, regulating vascular
remodelling, cardiac development and atherogenesis 1 , but the mechanisms of transduction …

Understanding mechanisms underlying human gene expression variation with RNA sequencing

…, JC Marioni, AA Pai, JF Degner, BE Engelhardt… - Nature, 2010 - nature.com
… Individual transcripts are numbered for reference in b. b, The inferred model for the
transcripts underlying the data in a. We plot the gene models inferred to result from splicing of …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

…, M Eich, P Engel, B Engelhardt… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical aspects of …

CC chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

…, S Lira, A Uccelli, A Lanzavecchia, B Engelhardt… - Nature …, 2009 - nature.com
… (b,c) CCL20 expression on normal human tissues (b) and in various areas of the brains
of patients with multiple sclerosis (MS; c), assessed by immunohistochemistry of formalin-fixed, …

Guidelines for the use of flow cytometry and cell sorting in immunological studies*

…, B Engelhardt, C Esser, B Everts… - European journal of …, 2017 - Wiley Online Library
From a technical point of view a flow cytometer is a light detection device capable of detecting
photons of different wavelengths over a high dynamic range. In order to achieve a high …

The movers and shapers in immune privilege of the CNS

B Engelhardt, P Vajkoczy, RO Weller - Nature immunology, 2017 - nature.com
… (a,b) Drainage pathways for CSF are very similar in the human (a) and rodent (b) brains.
CSF drains from the SAS through arachnoid villi into the blood of venous sinuses (villi are …

Capture, crawl, cross: the T cell code to breach the blood–brain barriers

B Engelhardt, RM Ransohoff - Trends in immunology, 2012 - cell.com
The central nervous system (CNS) is an immunologically privileged site to which access of
circulating immune cells is tightly controlled by the endothelial blood–brain barrier (BBB; see …