Background A systematic review was conducted to evaluate the literature regarding the
impact of follow-up on colorectal cancer patient survival and, in a second phase, …

The field of nanotechnology has grown over the last two decades and made the transition
from the benchtop to applied technologies. Nanoscale-sized particles, or nanoparticles, have …

… four lines of evidence that support using the aged canine as a model of human aging: (a)
Aged canines develop aspects of neuropathology similar to that observed in aged humans; (b) …

Large-scale reference data sets of human genetic variation are critical for the medical and
functional interpretation of DNA sequence changes. Here we describe the aggregation and …

Genetic variants that inactivate protein-coding genes are a powerful source of information
about the phenotypic consequences of gene disruption: genes that are crucial for the function …

Genetic variants that inactivate protein-coding genes are a powerful source of information
about the phenotypic consequences of gene disruption: genes critical for an organism’s …

Worldwide, hundreds of thousands of humans have had their genomes or exomes
sequenced, and access to the resulting data sets can provide valuable information for variant …

X chromosome inactivation (XCI) silences transcription from one of the two X chromosomes
in female mammalian cells to balance expression dosage between XX females and XY …

Exome and whole-genome sequencing are becoming increasingly routine approaches in
Mendelian disease diagnosis. Despite their success, the current diagnostic rate for genomic …

We report that prospectively isolated, human CNS stem cells grown as neurospheres (hCNS-SCns)
survive, migrate, and express differentiation markers for neurons and …