The role of X-inactivation is often ignored as a prime cause of sex differences in disease. Yet,
the way males and females express their X-linked genes has a major role in the dissimilar …

A complex and unique, apparently balanced translocation involving three autosomes and
an X in a phenotypically abnormal child is described. Family studies using glucose 6 …

A good deal of sex differences in kidney disease is attributable to sex differences in the
function of genes on the X chromosome. Males are uniquely vulnerable to mutations in their …

To explore the role of DNA methylation in maintaining dosage compensation of X
chromosome-linked genes and in regulating the transcriptional activity of "housekeeping" genes, we …

Skin fibroblasts of human males affected with adrenoleukodystrophy (ALD) have previously
been shown to be abnormal with respect to C26 fatty acid content. Skin fibroblast clones …

We developed an aqueous spreading procedure that permits simultaneous analysis of human
chromosomes by Q-banding and indirect immunofluorescence. Using this methodology …

Complete or ‘true’ hydatidiform mole, an abnormality of human gestation, is characterized by
hydropic degeneration of all placental villi, marked hypertrophy of the trophoblast, absence …

… Females are mosaics because X inactivation creates 2 populations of cells differing in
the parental origin of the active X (discussed in Migeon 6 ). As the active X is usually chosen …

A nutrient medium has been developed to enable the growth of normal epithellal cells while
selectively lnhlbltlng flbroblast proliferation. In this medium, D-vallne Is substituted for L-…

… Migeon has published more than 150 papers on the molecular mechanisms involved in X
chromosome inactivation in human cells and the clinical consequences of a single working X …