The endoplasmic reticulum (ER) provides an environment that is highly optimized for oxidative
protein folding. Rather than relying on small molecule oxidants like glutathione, it is now …

Acetyl-CoA represents a key node in metabolism due to its intersection with many metabolic
pathways and transformations. Emerging evidence reveals that cells monitor the levels of …

The evolutionary origins of periodic phenomena in biology, such as the circadian cycle, the
hibernation cycle and the sleep–wake cycle, remain a mystery. We discuss the concept of …

Human Immunodeficiency Viruses (HIV-1 and HIV-2) rely upon host-encoded proteins to
facilitate their replication. Here, we combined genome-wide siRNA analyses with interrogation …

Budding yeast grown under continuous, nutrient-limited conditions exhibit robust, highly
periodic cycles in the form of respiratory bursts. Microarray studies reveal that over half of the …

Influenza A virus is an RNA virus that encodes up to 11 proteins and this small coding capacity
demands that the virus use the host cellular machinery for many aspects of its life cycle 1 . …

Maintenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for
a wide variety of biological processes. We demonstrate that the N 6 -adenosine …

… PCR primers were designed by Primer Express software from Applied Biosystems to target
every $250 bp region from À750 bp before to 750 bp after the start codon of the selected gene…

… Because all six GBM HOT lines were generated from patient tumors prior to the initiation
of treatment, we next studied the tumor line generated from recurrent tumor (UT-GBM7) and …

… mice lacking ACSS2 exhibit a significant reduction in tumor burden in two different models of
… Using this method, we determined that approximately half of the ACSS2-positive tumors in …