This article reviews prefrontal cortical biology as it relates to pathophysiology and genetic
risk for schizophrenia. Studies of prefrontal neurocognition and functional neuroimaging of …

Animal modeling has been instrumental in dissecting pathophysiological mechanisms and
designing more effective therapies in many areas of medicine but not so in psychiatry. The …

Two of the favorite hypotheses of schizophrenia research — maldevelopment of cerebral
cortex and malfunction of brain dopamine systems — have often seemed difficult to reconcile. …

… Indeed, we recently reported (Lipska et a1. 1992) that an excitotoxic lesion of ventral
hippocampal (VH) formation in the adult rat enhanced spontaneous exploration and amphetamine …

Anatomical and molecular abnormalities of excitatory neurons in the dorsolateral prefrontal
cortex (DLPFC) are found in schizophrenia. We hypothesized that brain-derived neurotrophic …

Catechol-O-methyltransferase (COMT) is a key enzyme in the elimination of dopamine in the
prefrontal cortex of the human brain. Genetic variation in the COMT gene (MIM 116790) has …

Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral …

Previous investigations have combined transcriptional and genetic analyses in human cell
lines 1 , 2 , 3 , but few have applied these techniques to human neural tissue 4 , 5 , 6 , 7 , 8 . …

Catechol O-methyltransferase (COMT) is involved in the inactivation of catecholamines,
including the neurotransmitter dopamine. A Val 108/158 Met functional polymorphism of the …

Genetic variation in neuregulin 1 (NRG1) is associated with schizophrenia. The disease-associated
SNPs are noncoding, and their functional implications remain unknown. We …