User profiles for B. J. Keating
 | Brendan KeatingUniversity of Pennsylvania Verified email at mail.med.upenn.edu Cited by 34051 |
Mendelian randomization of blood lipids for coronary heart disease
Aims To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and
triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian …
triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian …
[HTML][HTML] HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
…, M Bobak, H Pikhart, JG Wilson, AP Reiner, BJ Keating… - The Lancet, 2015 - thelancet.com
Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl…
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl…
[HTML][HTML] Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies
BJ Keating, S Tischfield, SS Murray, T Bhangale… - PloS one, 2008 - journals.plos.org
A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans
has been accumulating over the last decade, in particular a large number of loci derived from …
has been accumulating over the last decade, in particular a large number of loci derived from …
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
…, M Kähönen, HM Kang, S Kathiresan, BJ Keating… - Nature …, 2016 - nature.com
To dissect the genetic architecture of blood pressure and assess effects on target organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …
[HTML][HTML] PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
Background Statin treatment and variants in the gene encoding HMG-CoA reductase are
associated with reductions in both the concentration of LDL cholesterol and the risk of coronary …
associated with reductions in both the concentration of LDL cholesterol and the risk of coronary …
[HTML][HTML] Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project
…, BE Henderson, JN Hirschhorn, BJ Keating… - PLoS …, 2011 - journals.plos.org
Coronary heart disease (CHD) is the leading cause of mortality in African Americans. To identify
common genetic polymorphisms associated with CHD and its risk factors (LDL- and HDL…
common genetic polymorphisms associated with CHD and its risk factors (LDL- and HDL…
The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319 , a novel gene involved in neuronal migration
…, M Paramasivam, Y Wang, BJ Keating… - Human molecular …, 2006 - academic.oup.com
Dyslexia is one of the most prevalent childhood cognitive disorders, affecting ∼5% of school-age
children. We have recently identified a risk haplotype associated with dyslexia on …
children. We have recently identified a risk haplotype associated with dyslexia on …
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry
…, VJ Howard, KC Johnson, SJ Kang, BJ Keating… - Nature …, 2013 - nature.com
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass
index (BMI), predominantly in populations of European ancestry. We conducted a meta-…
index (BMI), predominantly in populations of European ancestry. We conducted a meta-…
Association of lipid fractions with risks for coronary artery disease and diabetes
…, D Preiss, Z Fairhurst-Hunter, BJ Keating… - JAMA …, 2016 - jamanetwork.com
Importance Low-density lipoprotein cholesterol (LDL-C) is causally related to coronary
artery disease (CAD), but the relevance of high-density lipoprotein cholesterol (HDL-C) and …
artery disease (CAD), but the relevance of high-density lipoprotein cholesterol (HDL-C) and …
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases
Genome-wide association studies (GWASs) have identified hundreds of susceptibility genes,
including shared associations across clinically distinct autoimmune diseases. We …
including shared associations across clinically distinct autoimmune diseases. We …