Development of allergen-specific T-cell memory in atopic and normal children
… SL Prescott, C Macaubas, PD Sly, and PG Holt shared responsibility for design, analysis, …
Laboratory work was done by SL Prescott, with assistance from T Smallacombe and BJ Holt…
Laboratory work was done by SL Prescott, with assistance from T Smallacombe and BJ Holt…
[HTML][HTML] The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development
…, M Kusel, M Serralha, N Troy, BJ Holt, BJ Hales… - Cell host & …, 2015 - cell.com
The nasopharynx (NP) is a reservoir for microbes associated with acute respiratory
infections (ARIs). Lung inflammation resulting from ARIs during infancy is linked to asthma …
infections (ARIs). Lung inflammation resulting from ARIs during infancy is linked to asthma …
Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile
SL Prescott, C Macaubas, BJ Holt… - The Journal of …, 1998 - journals.aai.org
The expression of Th2-skewed immunity against soluble protein Ags present in the normal
environment is recognized as the primary cause of allergic inflammation in atopics. In contrast…
environment is recognized as the primary cause of allergic inflammation in atopics. In contrast…
Differential patterns of methylation of the IFN-γ promoter at CpG and non-CpG sites underlie differences in IFN-γ gene expression between human neonatal and adult …
IFN-γ is a potent pleiotropic Th1 cytokine, the production of which is tightly regulated during
fetal development. Negative control of fetal/neonatal IFN-γ production is generally attributed …
fetal development. Negative control of fetal/neonatal IFN-γ production is generally attributed …
Maternal serum vitamin D levels during pregnancy and offspring neurocognitive development
AJO Whitehouse, BJ Holt, M Serralha, PG Holt… - …, 2012 - publications.aap.org
OBJECTIVES: To determine the association between maternal serum 25(OH)-vitamin D
concentrations during a critical window of fetal neurodevelopment and behavioral, emotional, …
concentrations during a critical window of fetal neurodevelopment and behavioral, emotional, …
Association between antenatal cytokine production and the development of atopy and asthma at age 6 years
Background Various lines of evidence suggest that antenatal factors are important in determining
susceptibility to atopy and asthma. One possible mechanism is cytokines, production of …
susceptibility to atopy and asthma. One possible mechanism is cytokines, production of …
An immunoepidemiological approach to asthma: identification of in-vitro T cell response patterns associated with different wheezing phenotypes in children
Background Increasing evidence suggests that patterns of T cell immunity to inhalant
allergens in genetically diverse human populations are more heterogeneous than previously …
allergens in genetically diverse human populations are more heterogeneous than previously …
Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study
EM Hollams, PH Hart, BJ Holt… - European …, 2011 - Eur Respiratory Soc
Vitamin D has been linked in some studies with atopy- and asthma-associated phenotypes in
children with established disease, but its role in disease inception at the community level is …
children with established disease, but its role in disease inception at the community level is …
Development of interleukin-12-producing capacity throughout childhood
JW Upham, PT Lee, BJ Holt, T Heaton… - Infection and …, 2002 - Am Soc Microbiol
Increasing evidence indicates that the capacity to induce protective Th1 immune responses
is impaired in early childhood, an observation that can be partially attributed to deficiencies …
is impaired in early childhood, an observation that can be partially attributed to deficiencies …
Genetic 'risk'for atopy is associated with delayed postnatal maturation of T‐cell competence
PG Holt, JB Clough, BJ Holt… - Clinical & …, 1992 - Wiley Online Library
Recent in vitro studies suggest that IgE production in adults is co‐ordinately regulated by
negative signals from γIFN‐producing CD4 + T‐helper‐1 (TH‐1) and positive signals from IL‐4 …
negative signals from γIFN‐producing CD4 + T‐helper‐1 (TH‐1) and positive signals from IL‐4 …