User profiles for B. J. Blencowe

Benjamin J. Blencowe

Professor, University of Toronto
Verified email at utoronto.ca
Cited by 40197

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

Q Pan, O Shai, LJ Lee, BJ Frey, BJ Blencowe - Nature genetics, 2008 - nature.com
We carried out the first analysis of alternative splicing complexity in human tissues using
mRNA-Seq data. New splice junctions were detected in ∼20% of multiexon genes, many of …

[PDF][PDF] The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation

…, CF Bennett, A Sharma, PA Bubulya, BJ Blencowe… - Molecular cell, 2010 - cell.com
Alternative splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased
transcriptome and proteomic complexity. The serine/arginine (SR) splicing factors regulate …

A compendium of RNA-binding motifs for decoding gene regulation

…, LOF Penalva, EP Lei, AG Fraser, BJ Blencowe… - Nature, 2013 - nature.com
RNA-binding proteins are key regulators of gene expression, yet only a small fraction have
been functionally characterized. Here we report a systematic analysis of the RNA motifs …

The human splicing code reveals new insights into the genetic determinants of disease

…, N Jojic, SW Scherer, BJ Blencowe, BJ Frey - Science, 2015 - science.org
INTRODUCTION Advancing whole-genome precision medicine requires understanding
how gene expression is altered by genetic variants, especially those that are far outside of …

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

…, Y Tian, S Horvath, J Mill, RM Cantor, BJ Blencowe… - Nature, 2011 - nature.com
Autism spectrum disorder (ASD) is a common, highly heritable neurodevelopmental condition
characterized by marked genetic heterogeneity 1 , 2 , 3 . Thus, a fundamental question is …

The evolutionary landscape of alternative splicing in vertebrate species

…, MD Wilson, PM Kim, DT Odom, BJ Frey, BJ Blencowe - Science, 2012 - science.org
… Roth, and past and present members of the Blencowe laboratory for helpful discussions
and comments on the manuscript. Supported by grants from the Canadian Institutes of Health …

Deciphering the splicing code

…, W Gao, Q Pan, X Wang, O Shai, BJ Blencowe, BJ Frey - Nature, 2010 - nature.com
Alternative splicing has a crucial role in the generation of biological complexity, and its
misregulation is often involved in human disease. Here we describe the assembly of a ‘splicing …

[HTML][HTML] Alternative splicing: new insights from global analyses

BJ Blencowe - Cell, 2006 - cell.com
Recent analyses of sequence and microarray data have suggested that alternative splicing
plays a major role in the generation of proteomic and functional diversity in metazoan …

Regulation of alternative splicing by histone modifications

RF Luco, Q Pan, K Tominaga, BJ Blencowe… - Science, 2010 - science.org
Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet
its regulation is poorly understood. We demonstrated a direct role for histone modifications …

Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases

BJ Blencowe - Trends in biochemical sciences, 2000 - cell.com
Exonic splicing enhancers (ESEs) are discrete sequences within exons that promote both
constitutive and regulated splicing. The precise mechanism by which ESEs facilitate the …