User profiles for B. J. Blencowe
Benjamin J. BlencoweProfessor, University of Toronto Verified email at utoronto.ca Cited by 40197 |
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
We carried out the first analysis of alternative splicing complexity in human tissues using
mRNA-Seq data. New splice junctions were detected in ∼20% of multiexon genes, many of …
mRNA-Seq data. New splice junctions were detected in ∼20% of multiexon genes, many of …
[PDF][PDF] The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation
…, CF Bennett, A Sharma, PA Bubulya, BJ Blencowe… - Molecular cell, 2010 - cell.com
Alternative splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased
transcriptome and proteomic complexity. The serine/arginine (SR) splicing factors regulate …
transcriptome and proteomic complexity. The serine/arginine (SR) splicing factors regulate …
A compendium of RNA-binding motifs for decoding gene regulation
RNA-binding proteins are key regulators of gene expression, yet only a small fraction have
been functionally characterized. Here we report a systematic analysis of the RNA motifs …
been functionally characterized. Here we report a systematic analysis of the RNA motifs …
The human splicing code reveals new insights into the genetic determinants of disease
INTRODUCTION Advancing whole-genome precision medicine requires understanding
how gene expression is altered by genetic variants, especially those that are far outside of …
how gene expression is altered by genetic variants, especially those that are far outside of …
Transcriptomic analysis of autistic brain reveals convergent molecular pathology
Autism spectrum disorder (ASD) is a common, highly heritable neurodevelopmental condition
characterized by marked genetic heterogeneity 1 , 2 , 3 . Thus, a fundamental question is …
characterized by marked genetic heterogeneity 1 , 2 , 3 . Thus, a fundamental question is …
The evolutionary landscape of alternative splicing in vertebrate species
… Roth, and past and present members of the Blencowe laboratory for helpful discussions
and comments on the manuscript. Supported by grants from the Canadian Institutes of Health …
and comments on the manuscript. Supported by grants from the Canadian Institutes of Health …
Deciphering the splicing code
Alternative splicing has a crucial role in the generation of biological complexity, and its
misregulation is often involved in human disease. Here we describe the assembly of a ‘splicing …
misregulation is often involved in human disease. Here we describe the assembly of a ‘splicing …
[HTML][HTML] Alternative splicing: new insights from global analyses
BJ Blencowe - Cell, 2006 - cell.com
Recent analyses of sequence and microarray data have suggested that alternative splicing
plays a major role in the generation of proteomic and functional diversity in metazoan …
plays a major role in the generation of proteomic and functional diversity in metazoan …
Regulation of alternative splicing by histone modifications
Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet
its regulation is poorly understood. We demonstrated a direct role for histone modifications …
its regulation is poorly understood. We demonstrated a direct role for histone modifications …
Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases
BJ Blencowe - Trends in biochemical sciences, 2000 - cell.com
Exonic splicing enhancers (ESEs) are discrete sequences within exons that promote both
constitutive and regulated splicing. The precise mechanism by which ESEs facilitate the …
constitutive and regulated splicing. The precise mechanism by which ESEs facilitate the …