This review covers recent developments in the cellular neurophysiology of retrograde
signaling in the mammalian central nervous system. Normally at a chemical synapse a …

The endocannabinoid system consists of G-protein-coupled cannabinoid receptors that can
be activated by cannabis-derived drugs and small lipids termed endocannabinoids (eCBs) …

Endocannabinoids are lipid-derived messengers, and both their synthesis and breakdown
are under tight spatiotemporal regulation. As retrograde signalling molecules, …

Using intracellular recording techniques in CA1 cells in the hippocampal slice, we studied
the responses of cells to synaptically released and iontophoretically applied GABA. With high-…

Subregions of the rat hippocampal slice were investigateed in relation to (a) the presence of
long-term potentiation and (b) responsiveness to low-frequency stimulation. Long-term …

Endocannabinoids are key intercellular signaling molecules in the brain, but the physiological
regulation of the endocannabinoid system is not understood. We used the retrograde …

Synaptic excitation of hippocampal cells during blockade of synaptic inhibition results in an
epileptiform "burst" potential followed by a prolonged afterhyperpolarization. This …

… A preliminary report of this work has appeared (Alger & Nicoll, 1979). … The
modifiedexperimental chamber which we now use (Nicoll & Alger, 1981b) incorporates a …

Exogenous cannabinoids disrupt behavioral learning and impede induction of long-term
potentiation (LTP) in the hippocampus 1 , yet endogenous cannabinoids (endocannabinoids) 2 …

… In the preceding paper (Alger & Nicoll, 1982) we reported that in the presence of
pentobarbitone synaptically released GABA is capable of producing a depolarizing inhibitory …