The budding yeast Saccharomyces cerevisiae has been an invaluable model system for the
study of the establishment of cellular asymmetry and growth polarity in response to specific …

Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport
between the cytoplasm and nucleoplasm. However, their large size and dynamic nature have …

Mature mammalian oocytes are poised for completing meiosis II (MII) on fertilization by
positioning the spindle close to an actomyosin-rich cortical cap 1 , 2 , 3 . Here, we show that the …

Aggregation of damaged or misfolded proteins is a protective mechanism against proteotoxic
stress, abnormalities of which underlie many aging-related diseases. Here, we show that in …

During yeast cell division, aggregates of damaged proteins are segregated asymmetrically
between the bud and the mother. It is thought that protein aggregates are cleared from the …

The synaptonemal complex (SC), a structure highly conserved from yeast to mammals,
assembles between homologous chromosomes and is essential for accurate chromosome …

Fluorescence correlation spectroscopy (FCS), fluorescence cross-correlation spectroscopy (FCCS),
and photon counting histograms (PCH) are fluctuation methods that emerged …

Polar body extrusion during oocyte maturation is critically dependent on asymmetric positioning
of the meiotic spindle, which is established through migration of the meiosis I (MI) spindle…

In budding yeast, the highly conserved small GTPase Cdc42 localizes to the cortex at a cell
pole and orchestrates the trafficking and deposition of cell surface materials required for …

Memories are thought to be formed in response to transient experiences, in part through
changes in local protein synthesis at synapses. In Drosophila, the amyloidogenic (prion-like) …