NMDA-type glutamate receptors (NMDARs) mediate many forms of synaptic plasticity. These
tetrameric receptors consist of two obligatory NR1 subunits and two regulatory subunits, …

Angelman syndrome (AS) is a severe genetic disorder caused by mutations or deletions of
the maternally inherited UBE3A gene. UBE3A encodes an E3 ubiquitin ligase that is …

Various combinations of subunits assemble to form the NMDA-type glutamate receptor (NMDAR),
generating diversity in its functions. Here we review roles of the unique NMDAR …

Sensory experience is crucial in the refinement of synaptic connections in the brain during
development. It has been suggested that some forms of experience-dependent synaptic …

During neuronal activity, extracellular potassium concentration ([K + ] out ) becomes
elevated and, if uncorrected, causes neuronal depolarization, hyperexcitability, and seizures. …

Activation of group 1 metabotropic glutamate receptors (mGluRs) stimulates dendritic
protein synthesis and long-term synaptic depression (LTD), but it remains unclear how these …

SHANK3 is a synaptic scaffolding protein enriched in the postsynaptic density (PSD) of
excitatory synapses. Small microdeletions and point mutations in SHANK3 have been identified …

Calcineurin is a calcium-dependent protein phosphatase that has been implicated in various
aspects of synaptic plasticity. By using conditional gene-targeting techniques, we created …

The binocular region of mouse visual cortex is strongly dominated by inputs from the
contralateral eye. Here we show in adult mice that depriving the dominant contralateral eye of …

… Here we have extended this analysis to the effects of brief BD in LR animals. We begin with
… , and compare these with the effects of BD (produced by placing LR animals in a darkroom). …