Next-generation sequencing has generated a need for a broadly applicable method to
remove unwanted high-abundance species prior to sequencing. We introduce DASH (Depletion …

Importance Identifying infectious causes of subacute or chronic meningitis can be challenging.
Enhanced, unbiased diagnostic approaches are needed. Objective To present a case …

A 37-year-old man with a history of seminoma presented with vertigo, ataxia, and diplopia.
An autoantibody specific for kelch-like protein 11 (KLHL11) was identified with the use of …

Background Ocular infections remain a major cause of blindness and morbidity worldwide.
While prognosis is dependent on the timing and accuracy of diagnosis, the etiology remains …

Objective Identification of a particular cause of meningoencephalitis can be challenging owing
to the myriad bacteria, viruses, fungi, and parasites that can produce overlapping clinical …

Since 2012, the United States of America has experienced a biennial spike in pediatric
acute flaccid myelitis (AFM) 1 , 2 , 3 , 4 , 5 – 6 . Epidemiologic evidence suggests non-polio …

… , schizophrenia and bipolar disorder (BD), are among the … (GWAS) of schizophrenia and BD
have been published. These … the hypothesis that schizophrenia and BD are not aetiologically …

In engineering design, there is often considerable uncertainty in knowledge about the product,
for example, the lift generated by a wing might be unknown until wind tunnel tests have …

Neuropsychiatric disorders are complex conditions with poorly defined neurobiological bases.
In recent years, there have been significant advances in our understanding of the genetic …

Objective: Therapeutic options are limited for treatment-resistant bipolar depression (TRBD).
Insulin resistance (IR) confers increased risk for TRBD. We investigated metformin, an …