Many research questions in fields such as personalized medicine, drug screens or systems
biology depend on obtaining consistent and quantitatively accurate proteomics data from …

In this Perspective, we discuss developments in mass-spectrometry-based proteomic
technology over the past decade from the viewpoint of our laboratory. We also reflect on existing …

Advancements in mass spectrometry‐based proteomics have enabled experiments encompassing
hundreds of samples. While these large sample sets deliver much‐needed statistical …

Data-independent acquisition modes isolate and concurrently fragment populations of different
precursors by cycling through segments of a predefined precursor m/z range. Although …

… Ben C Collins … Hannes L Röst, George Rosenberger, Pedro Navarro, Ludovic Gillet, Saša
M Miladinović, Olga T Schubert, Ben C Collins, Lars Malmström & Ruedi … Ben C Collins …

Quantitative proteomics employing mass spectrometry is an indispensable tool in life science
research. Targeted proteomics has emerged as a powerful approach for reproducible …

Mass spectrometry is the method of choice for deep and reliable exploration of the (human)
proteome. Targeted mass spectrometry reliably detects and quantifies pre-determined sets of …

Clinical specimens are each inherently unique, limited and nonrenewable. Small samples
such as tissue biopsies are often completely consumed after a limited number of analyses. …

Protein complexes and protein interaction networks are essential mediators of most
biological functions. Complexes supporting transient functions such as signal transduction …

The degree and the origins of quantitative variability of most human plasma proteins are
largely unknown. Because the twin study design provides a natural opportunity to estimate the …