User profiles for B. B. Khomtchouk
Bohdan KhomtchoukAssistant Professor, Indiana University Verified email at iu.edu Cited by 567 |
[HTML][HTML] shinyheatmap: Ultra fast low memory heatmap web interface for big data genomics
BB Khomtchouk, JR Hennessy, C Wahlestedt - PloS one, 2017 - journals.plos.org
… The methods are implemented in R, and are available as part of the shinyheatmap project
at: https://github.com/Bohdan-Khomtchouk/shinyheatmap . Users can access fastheatmap …
at: https://github.com/Bohdan-Khomtchouk/shinyheatmap . Users can access fastheatmap …
[HTML][HTML] HeatmapGenerator: high performance RNAseq and microarray visualization software suite to examine differential gene expression levels using an R and C++ …
BB Khomtchouk, DJ Van Booven… - Source code for biology …, 2014 - Springer
Background The graphical visualization of gene expression data using heatmaps has become
an integral component of modern-day medical research. Heatmaps are used extensively …
an integral component of modern-day medical research. Heatmaps are used extensively …
Targeting the cytoskeleton and extracellular matrix in cardiovascular disease drug discovery
BB Khomtchouk, YS Lee, ML Khan, P Sun… - Expert opinion on …, 2022 - Taylor & Francis
… BB Khomtchouk. The authors also acknowledge that ML Khan is supported by the University
of Chicago Micro-Metcalf Program while YS Lee is supported by the University of Chicago …
of Chicago Micro-Metcalf Program while YS Lee is supported by the University of Chicago …
[HTML][HTML] Enhanced single-cell RNA-seq workflow reveals coronary artery disease cellular cross-talk and candidate drug targets
Background and aims The atherosclerotic plaque microenvironment is highly complex, and
selective agents that modulate plaque stability are not yet available. We sought to develop a …
selective agents that modulate plaque stability are not yet available. We sought to develop a …
[HTML][HTML] Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2
Epigenetic processes have been implicated in the pathophysiology of alcohol dependence,
but the specific molecular mechanisms mediating dependence-induced neuroadaptations …
but the specific molecular mechanisms mediating dependence-induced neuroadaptations …
Cardioinformatics: the nexus of bioinformatics and precision cardiology
BB Khomtchouk, DT Tran, KA Vand… - Briefings in …, 2020 - academic.oup.com
Cardiovascular disease (CVD) is the leading cause of death worldwide, causing over 17
million deaths per year, which outpaces global cancer mortality rates. Despite these sobering …
million deaths per year, which outpaces global cancer mortality rates. Despite these sobering …
Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways
Epigenetic enzymes oversee long‐term changes in gene expression by integrating genetic
and environmental cues. While there are hundreds of enzymes that control histone and DNA …
and environmental cues. While there are hundreds of enzymes that control histone and DNA …
[HTML][HTML] Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression
…, F Fasolo, Z Wu, A Bäcklund, BB Khomtchouk… - Molecular Therapy, 2023 - cell.com
Long non-coding RNAs (lncRNAs) orchestrate various biological processes and regulate
the development of cardiovascular diseases. Their potential therapeutic benefit to tackle …
the development of cardiovascular diseases. Their potential therapeutic benefit to tackle …
[HTML][HTML] Treatment with a neutrophil elastase inhibitor and ofloxacin reduces P. aeruginosa burden in a mouse model of chronic suppurative otitis media
KM Khomtchouk, LI Joseph, BB Khomtchouk… - npj Biofilms and …, 2021 - nature.com
Chronic suppurative otitis media (CSOM) is a widespread, debilitating problem with poorly
understood immunology. Here, we assess the host response to middle ear infection over the …
understood immunology. Here, we assess the host response to middle ear infection over the …
[HTML][HTML] Machine learning classifiers predict key genomic and evolutionary traits across the kingdoms of life
L Hallee, BB Khomtchouk - Scientific Reports, 2023 - nature.com
In this study, we investigate how an organism’s codon usage bias can serve as a predictor
and classifier of various genomic and evolutionary traits across the domains of life. We …
and classifier of various genomic and evolutionary traits across the domains of life. We …