User profiles for B. B. Khomtchouk

Bohdan Khomtchouk

Assistant Professor, Indiana University
Verified email at iu.edu
Cited by 567

[HTML][HTML] shinyheatmap: Ultra fast low memory heatmap web interface for big data genomics

BB Khomtchouk, JR Hennessy, C Wahlestedt - PloS one, 2017 - journals.plos.org
… The methods are implemented in R, and are available as part of the shinyheatmap project
at: https://github.com/Bohdan-Khomtchouk/shinyheatmap . Users can access fastheatmap …

[HTML][HTML] HeatmapGenerator: high performance RNAseq and microarray visualization software suite to examine differential gene expression levels using an R and C++ …

BB Khomtchouk, DJ Van Booven… - Source code for biology …, 2014 - Springer
Background The graphical visualization of gene expression data using heatmaps has become
an integral component of modern-day medical research. Heatmaps are used extensively …

Targeting the cytoskeleton and extracellular matrix in cardiovascular disease drug discovery

BB Khomtchouk, YS Lee, ML Khan, P Sun… - Expert opinion on …, 2022 - Taylor & Francis
BB Khomtchouk. The authors also acknowledge that ML Khan is supported by the University
of Chicago Micro-Metcalf Program while YS Lee is supported by the University of Chicago …

[HTML][HTML] Enhanced single-cell RNA-seq workflow reveals coronary artery disease cellular cross-talk and candidate drug targets

…, M Mokry, SW van der Laan, BB Khomtchouk… - Atherosclerosis, 2022 - Elsevier
Background and aims The atherosclerotic plaque microenvironment is highly complex, and
selective agents that modulate plaque stability are not yet available. We sought to develop a …

[HTML][HTML] Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2

E Barbier, AL Johnstone, BB Khomtchouk… - Molecular …, 2017 - nature.com
Epigenetic processes have been implicated in the pathophysiology of alcohol dependence,
but the specific molecular mechanisms mediating dependence-induced neuroadaptations …

Cardioinformatics: the nexus of bioinformatics and precision cardiology

BB Khomtchouk, DT Tran, KA Vand… - Briefings in …, 2020 - academic.oup.com
Cardiovascular disease (CVD) is the leading cause of death worldwide, causing over 17
million deaths per year, which outpaces global cancer mortality rates. Despite these sobering …

Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways

…, NS Andrade, E Barbier, BB Khomtchouk… - Addiction …, 2021 - Wiley Online Library
Epigenetic enzymes oversee long‐term changes in gene expression by integrating genetic
and environmental cues. While there are hundreds of enzymes that control histone and DNA …

[HTML][HTML] Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression

…, F Fasolo, Z Wu, A Bäcklund, BB Khomtchouk… - Molecular Therapy, 2023 - cell.com
Long non-coding RNAs (lncRNAs) orchestrate various biological processes and regulate
the development of cardiovascular diseases. Their potential therapeutic benefit to tackle …

[HTML][HTML] Treatment with a neutrophil elastase inhibitor and ofloxacin reduces P. aeruginosa burden in a mouse model of chronic suppurative otitis media

KM Khomtchouk, LI Joseph, BB Khomtchouk… - npj Biofilms and …, 2021 - nature.com
Chronic suppurative otitis media (CSOM) is a widespread, debilitating problem with poorly
understood immunology. Here, we assess the host response to middle ear infection over the …

[HTML][HTML] Machine learning classifiers predict key genomic and evolutionary traits across the kingdoms of life

L Hallee, BB Khomtchouk - Scientific Reports, 2023 - nature.com
In this study, we investigate how an organism’s codon usage bias can serve as a predictor
and classifier of various genomic and evolutionary traits across the domains of life. We …