Repair of DNA interstrand crosslinks requires action of multiple DNA repair pathways, including
homologous recombination. Here, we report a de novo heterozygous T131P mutation in …

Biomolecular condensates organize cellular functions in the absence of membranes. These
membraneless organelles can form through liquid–liquid phase separation coalescing RNA …

Alzheimer’s disease (AD) is characterized by accumulation of the β-amyloid peptide (Aβ),
which likely contributes to disease via multiple mechanisms. Increasing evidence implicates …

The protection and efficient restart of stalled replication forks is critical for the maintenance
of genome integrity. Here, we identify a regulatory pathway that promotes stalled forks …

Deficiency of FANCD2/FANCI-associated nuclease 1 (FAN1) in humans leads to karyomegalic
interstitial nephritis (KIN), a rare hereditary kidney disease characterized by chronic renal …

… Jakimenko, by funds from the Coleman Foundation to ZT Schafer, by funds from the
Notre Dame Glynn Family Honors Program to BA Conti, and by a Notre Dame Departmental …

DNA replication is a highly regulated process during which the genetic information of the
cell is duplicated. The replication machinery encounters many challenges that threaten the …

DNA replication through a challenging genomic landscape is coordinated by the replisome,
which must adjust to local conditions to provide appropriate replication speed and respond …

Severe cellular sensitivity and aberrant chromosomal rearrangements in response to DNA
interstrand crosslink (ICL) inducing agents are hallmarks of Fanconi anemia (FA) deficient …

… binaries with periods less than 2.5 days rotate too rapid Conti (1968a) pointed out that the
fraction of … The a few single Am stars (Conti 1969a) is then not surprisin ly, duplicity cannot be …