Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can
be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous …

Somatic cells can be inefficiently and stochastically reprogrammed into induced pluripotent
stem (iPS) cells by exogenous expression of Oct4 (also called Pou5f1), Sox2, Klf4 and Myc (…

Induced pluripotent stem cells (iPSCs) can be derived from somatic cells by ectopic expression
of different transcription factors, classically Oct4 (also known as Pou5f1), Sox2, Klf4 and …

In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-free
DNA (cfDNA) shows promise in detecting cancer mutations, we found that the …

Abstract Treatment of chronic lymphocytic leukemia (CLL) has shifted from chemo-immunotherapy
to targeted agents. To define the evolutionary dynamics induced by targeted therapy …

Somatic cells can be transdifferentiated to other cell types without passing through a
pluripotent state by ectopic expression of appropriate transcription factors 1 , 2 . Recent reports …

Mbd3, a member of nucleosome remodeling and deacetylase (NuRD) co-repressor complex,
was previously identified as an inhibitor for deterministic induced pluripotent stem cell (…

The epigenetic dynamics of induced pluripotent stem cell (iPSC) reprogramming in correctly
reprogrammed cells at high resolution and throughout the entire process remain largely …

Leukemia stem cells (LSCs) are believed to have more distinct vulnerabilities than the bulk
acute myeloid leukemia (AML) cells, but their rarity and the lack of universal markers for their …

A Fork-Join Network (FJN) is a natural model for a queueing system in which customers, or
rather tasks associated with customers, are processed both sequentially and in parallel. In …