Type 2 diabetes is one of the major chronic diseases accounting for a substantial proportion
of disease burden in Western countries. The majority of the burden of type 2 diabetes is …

Recent genetic studies have revealed shared immunological mechanisms in several
immune-related disorders that further our understanding of the development and concomitance of …

The human gut microbiome is a complex ecosystem that can mediate the interaction of the
human host with their environment. The interaction between gut microbes and commonly …

A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

Human gut microbiome composition is shaped by multiple factors but the relative contribution
of host genetics remains elusive. Here we examine genotype and microbiome data from …

Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based
cohort shows relations between the microbiome and 126 exogenous and intrinsic host …

To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium
curated and analyzed genome-wide genotypes and 16S fecal microbiome data from …

To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …

Identifying the downstream effects of disease-associated SNPs is challenging. To help
overcome this problem, we performed expression quantitative trait locus (eQTL) meta-analysis in …

Fecal microbiome variation in the average, healthy population has remained under-investigated.
Here, we analyzed two independent, extensively phenotyped cohorts: the Belgian …