The mammalian cerebral cortex supports cognitive functions such as sensorimotor
integration, memory, and social behaviors. Normal brain function relies on a diverse set of …

RNA abundance is a powerful indicator of the state of individual cells. Single-cell RNA
sequencing can reveal RNA abundance with high quantitative accuracy, sensitivity and …

The mammalian nervous system executes complex behaviors controlled by specialized,
precisely positioned, and interacting cell types. Here, we used RNA sequencing of half a million …

Oligodendrocytes have been considered as a functionally homogeneous population in the
central nervous system (CNS). We performed single-cell RNA sequencing on 5072 cells of …

Single-cell RNA sequencing (RNA-seq) is a powerful tool to reveal cellular heterogeneity,
discover new cell types and characterize tumor microevolution. However, losses in cDNA …

Understanding human embryonic ventral midbrain is of major interest for Parkinson’s
disease. However, the cell types, their gene expression dynamics, and their relationship to …

The hypothalamus contains the highest diversity of neurons in the brain. Many of these
neurons can co-release neurotransmitters and neuropeptides in a use-dependent manner. …

Global efforts to create a molecular census of the brain using single-cell transcriptomics are
producing a large catalog of molecularly defined cell types. However, spatial information is …

Traditionally, neuroscientists have defined the identity of neurons by the cells' location,
morphology, connectivity and excitability. However, the direct relationship between these …

The dorsal horn of the spinal cord is critical to processing distinct modalities of noxious and
innocuous sensation, but little is known of the neuronal subtypes involved, hampering efforts …