Polarization of macrophages to M1 or M2 cells is important for mounting responses against
bacterial and helminth infections, respectively. Jumonji domain containing-3 (Jmjd3), a …

Regnase-1 (also known as Zc3h12a and MCPIP1) is an RNase that destabilizes a set of
mRNAs, including Il6 and Il12b, through cleavage of their 3′ UTRs. Although Regnase-1 …

Most Foxp3+ regulatory T (T reg) cells develop in the thymus as a functionally mature T cell
subpopulation specialized for immune suppression. Their cell fate appears to be determined …

Regnase-1 and Roquin are RNA binding proteins essential for degradation of inflammation-related
mRNAs and maintenance of immune homeostasis. However, their mechanistic …

Naturally occurring regulatory T (Treg) cells, which specifically express the transcription
factor forkhead box P3 (Foxp3), are engaged in the maintenance of immunological self-…

Codon bias has been implicated as one of the major factors contributing to mRNA stability
in several model organisms. However, the molecular mechanisms of codon bias on mRNA …

Transcription of inflammatory genes in innate immune cells is coordinately regulated by
transcription factors, including NF ‐κB, and chromatin modifiers. However, it remains unclear …

During erythroid differentiation, the maintenance of genome integrity is key for the success
of multiple rounds of cell division. However, molecular mechanisms coordinating the …

Jdp2 is an AP-1 family transcription factor that regulates the epigenetic status of histones.
Previous in vitro studies revealed that Jdp2 is involved in osteoclastogenesis. However, the …

MO, K. Ozasa, EK, KK, K. Ohata, WI, TI, TK, TA, and KJI designed and performed the
immunological research and analyzed the data. M. Kitano, KT, TH, M. Kobayashi, and AS designed …