Genome-wide association studies have recently identified ten common genetic variants
associated with colorectal cancer susceptibility, several suggesting the involvement of …

General intelligence is an important human quantitative trait that accounts for much of the
variation in diverse cognitive abilities. Individual differences in intelligence are strongly …

Background Previous studies have shown that aspirin and other non-steroidal anti-inflammatory
drugs (NSAIDs) lower colorectal cancer (CRC) risk. However, the lowest effective …

Relatives provide the basic material for the study of inheritance of human disease. However,
the methodologies for the estimation of heritability and the interpretation of the results have …

Estimating individual genome-wide autozygosity is important both in the identification of
recessive disease variants via homozygosity mapping and in the investigation of the effects of …

Parkinson's disease is a common disorder that leads to motor and cognitive disability. We
performed a genome-wide association study of 2,000 individuals with Parkinson's disease (…

Genome-wide association (GWA) studies have identified multiple loci at which common variants
modestly influence the risk of developing colorectal cancer (CRC). To enhance power to …

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory
arthritis. By combining data from >140,000 individuals of European ancestry within the Global …

Background The identification of mutations in germ-line DNA mismatch-repair genes at the
time of diagnosis of colorectal cancer is important in the management of the disease. …

Platelets are the second most abundant cell type in blood and are essential for maintaining
haemostasis. Their count and volume are tightly controlled within narrow physiological …