Genome-wide association studies (GWAS) have laid the foundation for investigations into the
biology of complex traits, drug development and clinical guidelines. However, the majority …

The possibility of voyaging contact between prehistoric Polynesian and Native American
populations has long intrigued researchers. Proponents have pointed to the existence of New …

Approximately 15 genes have been directly associated with skin pigmentation variation in
humans, leading to its characterization as a relatively simple trait. However, by assembling a …

The extent to which prehistoric migrations of farmers influenced the genetic pool of western
North Africans remains unclear. Archaeological evidence suggests that the Neolithization …

Polynesia was settled in a series of extraordinary voyages across an ocean spanning one
third of the Earth 1 , but the sequences of islands settled remain unknown and their timings …

Domestication has had a strong impact on the development of modern societies. We sequenced
200 genomes of the chocolate plant Theobroma cacao L. to show for the first time to our …

The earliest events during human tumour initiation, although poorly characterized, may hold
clues to malignancy detection and prevention 1 . Here we model occult preneoplasia by …

We establish the first human forward genetic modeling of a commonly mutated tumor
suppressor gene, ARID1A . Our study integrates diverse modalities including CRISPR/Cas9 …

Preeclampsia is a multi-organ complication of pregnancy characterized by sudden
hypertension and proteinuria that is among the leading causes of preterm delivery and maternal …

The earliest events during human tumor initiation, while poorly characterized, may hold
clues to malignancy detection and prevention 1 . Here we model occult pre-neoplasia by bi-…