The extent of tumor heterogeneity is an emerging theme that researchers are only beginning
to understand. How genetic and epigenetic heterogeneity affects tumor evolution and …

The visual world offers a variety of information that enables animals to orient themselves to
their surroundings. One specific feature of the visual information is the wavelength difference …

Studies of a variety of higher cognitive functions consistently activate a region of anterior
cingulate cortex (ACC), situated posterior to the genu and superior to the corpus callosum. …

Deep brain stimulation (DBS) is an effective treatment for movement disorders, but the
mechanisms are unclear. DBS generates inhibition of neurons surrounding the electrode while …

Background Immune checkpoint inhibitors are effective cancer treatments, but molecular
determinants of clinical benefit are unknown. Ipilimumab and tremelimumab are antibodies …

Immune checkpoint inhibitors, which unleash a patient’s own T cells to kill tumors, are
revolutionizing cancer treatment. To unravel the genomic determinants of response to this therapy, …

As tumors grow, they acquire mutations, some of which create neoantigens that influence
the response of patients to immune checkpoint inhibitors. We explored the impact of …

We show that DNA methyltransferase inhibitors (DNMTis) upregulate immune signaling in
cancer through the viral defense pathway. In ovarian cancer (OC), DNMTis trigger cytosolic …

Here, we demonstrate that subject motion produces substantial changes in the timecourses
of resting state functional connectivity MRI (rs-fcMRI) data despite compensatory spatial …

This book on the theoretical analysis of optiCal waveguide propagation joins the handful of
texts concerned solely with the fundamental physics and mathematics of phenomena …