Over the past three decades the protein folding field has undergone monumental changes.
Originally a purely academic question, how a protein folds has now become vital in …

Highlights • The natural variation of proteins is a consequence of both biophysics and
population dynamics. • Recent theoretical and computational efforts integrate biophysics and …

Deletion of phenylalanine-508 (Phe-508) from the N-terminal nucleotide-binding domain (NBD1)
of the cystic fibrosis transmembrane conductance regulator (CFTR), a member of the …

… Author links open overlay panel Shimon Bershtein 1 , Adrian WR Serohijos 2 , Eugene I …
(4), (5), (6) Serohijos et al. showed that epistasis is prevalent but generally weak [79]. …

What are the molecular properties of proteins that fall on the radar of protein quality control (PQC)?
Here we mutate the E. coli's gene encoding dihydrofolate reductase (DHFR) and …

The cystic fibrosis transmembrane conductance regulator (CFTR) is a unique ATP-binding
cassette (ABC) ion channel mutated in patients with cystic fibrosis. The most common mutation…

The consistent observation across all kingdoms of life that highly abundant proteins evolve
slowly demonstrates that cellular abundance is a key determinant of protein evolutionary rate. …

Viral evolutionary pathways are determined by the fitness landscape, which maps viral
genotype to fitness. However, a quantitative description of the landscape and the evolutionary …

Since divergence ∼50 Ma ago from their terrestrial ancestors, cetaceans underwent a series
of adaptations such as a ∼10–20 fold increase in myoglobin (Mb) concentration in skeletal …

Horizontal gene transfer (HGT) plays a central role in bacterial evolution, yet the molecular
and cellular constraints on functional integration of the foreign genes are poorly understood. …