Droplet microfluidics offers significant advantages for performing high-throughput screens
and sensitive assays. Droplets allow sample volumes to be significantly reduced, leading to …

The mechanical behaviour of four types of composite material in various laminate lay-ups is
examined by using the Rotem failure criterion. The criterion distinguishes between fibre …

To explore the distinct genotypic and phenotypic states of melanoma tumors, we applied
single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 patients, profiling …

Chromatin profiling provides a versatile means to investigate functional genomic elements
and their regulation. However, current methods yield ensemble profiles that are insensitive to …

Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd)
tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To …

Immune checkpoint blockade (ICB) results in durable disease control in a subset of patients
with advanced renal cell carcinoma (RCC), but mechanisms driving resistance are poorly …

As the second year of the COVID-19 pandemic begins, it remains clear that a massive
increase in the ability to test for SARS-CoV-2 infections in a myriad of settings is critical to …

Ex vivo systems that incorporate features of the tumor microenvironment and model the
dynamic response to immune checkpoint blockade (ICB) may facilitate efforts in precision …

At present, proven clinical treatments but no cures are available for diabetes, a global epidemic
with a huge economic burden. Transplantation of islets of Langerhans by their infusion …

Transplantation of pancreatic islets is emerging as a successful treatment for type-1 diabetes.
Its current stringent restriction to patients with critical metabolic lability is justified by the …