This paper presents a new programming language, BlenX . BlenX is inspired to the process
calculus Beta-binders and it is intended for modelling any system whose basic step of …

The analysis of exonic DNA from prostate cancers has identified recurrently mutated genes,
but the spectrum of genome-wide alterations has not been profiled extensively in this …

Androgen receptor (AR) gene aberrations are rare in prostate cancer before primary hormone
treatment but emerge with castration resistance. To determine AR gene status using a …

Importance Understanding molecular mechanisms of response and resistance to anticancer
therapies requires prospective patient follow-up and clinical and functional validation of …

It is unclear whether a single clone metastasizes and remains dominant over the course of
lethal prostate cancer. We describe the clonal architectural heterogeneity at different stages of …

We evaluated ancestry effects on mutation rates, DNA methylation, and mRNA and miRNA
expression among 10,678 patients across 33 cancer types from The Cancer Genome Atlas. …

Loss of androgen receptor (AR) signaling dependence occurs in approximately 15%–20%
of advanced treatment-resistant prostate cancers, and this may manifest clinically as …

Despite the utility of CRISPR–Cas9 nucleases for genome editing, the potential for off-target
activity limits their application, especially for therapeutic purposes 1 , 2 . We developed a …

African-American men have the highest incidence of and mortality from prostate cancer.
Whether a biological basis exists for this disparity remains unclear. Exome sequencing (n = 102) …

Background There is an urgent need to identify biomarkers to guide personalized therapy in
castration-resistant prostate cancer (CRPC). We aimed to clinically qualify androgen …