The defining hallmark of stem cells is their ability to self-renew and maintain multipotency.
This capacity depends on the balance of complex signals in their microenvironment. Low …

Background and purpose While the combination of stereotactic radiosurgery (SRS) and
immune checkpoint inhibitors (ICI) is becoming more widely used in the treatment of brain …

OBJECTIVE: Thrombotic aneurysms are a diverse collection of complex aneurysms
characterized by organized intraluminal thrombus and solid mass. Consequently, their treatment …

The subventricular zone (SVZ) is a principal source of adult neural stem cells in the rodent
brain, generating thousands of olfactory bulb neurons every day 1 . If the adult human brain …

Object Gliadel (BCNU) wafer and concomitant temozolomide (TMZ) therapy, when used
individually as adjuvant therapies, extend survival from that achieved by resection and radiation …

More complete brain cancer resection can prolong survival and delay recurrence. However,
it is challenging to distinguish cancer from noncancer tissues intraoperatively, especially at …

The lateral wall of the lateral ventricle in the human brain contains neural stem cells
throughout adult life. We conducted a cytoarchitectural and ultrastructural study in complete …

Current glioblastoma therapies are insufficient to prevent tumor recurrence and eventual
death. Here, we describe a method to treat malignant glioma by nonviral DNA delivery using …

Object Glioblastoma is the most common and aggressive type of primary brain tumor in adults.
These tumors recur regardless of intervention. This propensity to recur despite aggressive …

OBJECTIVE: It remains unknown whether the extent of surgical resection affects survival or
disease progression in patients with supratentorial low-grade gliomas. METHODS: We …