Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …

Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic
glioma driving alterations and suboptimal disease classification. We defined the complete …

Telomere dysfunction activates p53-mediated cellular growth arrest, senescence and apoptosis
to drive progressive atrophy and functional decline in high-turnover tissues. The broader …

The involvement of whole-chromosome aneuploidy in tumorigenesis is the subject of debate,
in large part because of the lack of insight into underlying mechanisms. Here we identify a …

Melanoma is notable for its metastatic propensity, lethality in the advanced setting and
association with ultraviolet exposure early in life 1 . To obtain a comprehensive genomic view of …

An ageing world population has fuelled interest in regenerative remedies that may stem
declining organ function and maintain fitness. Unanswered is whether elimination of intrinsic …

Exosomes are small vesicles (50–150 nm) of endocytic origin that are released by many
different cell types. Exosomes in the tumor microenvironment may play a key role in facilitating …

Cancers are composed of populations of cells with distinct molecular and phenotypic features,
a phenomenon termed intratumor heterogeneity (ITH). ITH in lung cancers has not been …

We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell
carcinomas (ChRCCs) on the basis of multidimensional and comprehensive characterization, …

Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four molecularly
distinct, clinically relevant subtypes: two associated with poor-prognosis monosomy 3 (M3…