User profiles for A. Platt

Alexander Platt

- Verified email at alexanderplatt.org - Cited by 5122

Adam Platt

- Verified email at sky.com - Cited by 4725

Andrew Platt

- Verified email at nih.gov - Cited by 827

Drug development in the era of precision medicine

SA Dugger, A Platt, DB Goldstein - Nature reviews Drug discovery, 2018 - nature.com
For the past three decades, the use of genomics to inform drug discovery and development
pipelines has generated both excitement and scepticism. Although earlier efforts successfully …

Monocyte trafficking in acute and chronic inflammation

MA Ingersoll, AM Platt, S Potteaux, GJ Randolph - Trends in immunology, 2011 - cell.com
Environmental signals at the site of inflammation mediate rapid monocyte mobilization and
dictate differentiation programs whereby these cells give rise to macrophages or dendritic …

[HTML][HTML] Aspergillosis complicating severe coronavirus disease

KA Marr, A Platt, JA Tornheim, SX Zhang… - Emerging infectious …, 2021 - ncbi.nlm.nih.gov
Aspergillosis complicating severe influenza infection has been increasingly detected worldwide.
Recently, coronavirus disease–associated pulmonary aspergillosis (CAPA) has been …

[BOOK][B] The child savers: The invention of delinquency

AM Platt - 1977 - books.google.com
Anthony Platt's study, a chronicle of the child-saving movement and the juvenile court, explodes
myth after myth about the benign character of both. The movement is described not as …

Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines

…, G Willems, M Horton, Y Li, D Meng, A Platt… - Nature, 2010 - nature.com
Although pioneered by human geneticists as a potential solution to the challenging problem
of finding the genetic basis of common human diseases 1 , 2 , genome-wide association (…

[HTML][HTML] SARS-CoV-2 infection and persistence in the human body and brain at autopsy

…, J Sun, JM Dickey, K Ylaya, SH Ko, AP Platt… - Nature, 2022 - nature.com
Coronavirus disease 2019 (COVID-19) is known to cause multi-organ dysfunction 1 , 2 – 3
during acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), …

FinnGen: Unique genetic insights from combining isolated population and national health register data

…, RK Pendergrass, S Petrovski, A Pitkäranta, A Platt… - MedRxiv, 2022 - medrxiv.org
Population isolates such as Finland provide benefits in genetic studies because the allelic
spectrum of damaging alleles in any gene is often concentrated on a small number of low-…

An efficient multi-locus mixed-model approach for genome-wide association studies in structured populations

V Segura, BJ Vilhjálmsson, A Platt, A Korte, Ü Seren… - Nature …, 2012 - nature.com
Population structure causes genome-wide linkage disequilibrium between unlinked loci,
leading to statistical confounding in genome-wide association studies. Mixed models have …

Sustainable university: what can be the matter?

L Velazquez, N Munguia, A Platt, J Taddei - Journal of cleaner production, 2006 - Elsevier
This article presents a comprehensive managerial model for a sustainable university
created by D.Sc. L. Velazquez with empirical data collected from about 80 higher education …

[HTML][HTML] Rare variant contribution to human disease in 281,104 UK Biobank exomes

…, H Olsson, S Wasilewski, KR Smith, R March, A Platt… - Nature, 2021 - nature.com
Genome-wide association studies have uncovered thousands of common variants associated
with human disease, but the contribution of rare variants to common disease remains …