Drug development in the era of precision medicine
SA Dugger, A Platt, DB Goldstein - Nature reviews Drug discovery, 2018 - nature.com
For the past three decades, the use of genomics to inform drug discovery and development
pipelines has generated both excitement and scepticism. Although earlier efforts successfully …
pipelines has generated both excitement and scepticism. Although earlier efforts successfully …
Monocyte trafficking in acute and chronic inflammation
MA Ingersoll, AM Platt, S Potteaux, GJ Randolph - Trends in immunology, 2011 - cell.com
Environmental signals at the site of inflammation mediate rapid monocyte mobilization and
dictate differentiation programs whereby these cells give rise to macrophages or dendritic …
dictate differentiation programs whereby these cells give rise to macrophages or dendritic …
[HTML][HTML] Aspergillosis complicating severe coronavirus disease
Aspergillosis complicating severe influenza infection has been increasingly detected worldwide.
Recently, coronavirus disease–associated pulmonary aspergillosis (CAPA) has been …
Recently, coronavirus disease–associated pulmonary aspergillosis (CAPA) has been …
[BOOK][B] The child savers: The invention of delinquency
AM Platt - 1977 - books.google.com
Anthony Platt's study, a chronicle of the child-saving movement and the juvenile court, explodes
myth after myth about the benign character of both. The movement is described not as …
myth after myth about the benign character of both. The movement is described not as …
Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines
Although pioneered by human geneticists as a potential solution to the challenging problem
of finding the genetic basis of common human diseases 1 , 2 , genome-wide association (…
of finding the genetic basis of common human diseases 1 , 2 , genome-wide association (…
[HTML][HTML] SARS-CoV-2 infection and persistence in the human body and brain at autopsy
Coronavirus disease 2019 (COVID-19) is known to cause multi-organ dysfunction 1 , 2 – 3
during acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), …
during acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), …
FinnGen: Unique genetic insights from combining isolated population and national health register data
Population isolates such as Finland provide benefits in genetic studies because the allelic
spectrum of damaging alleles in any gene is often concentrated on a small number of low-…
spectrum of damaging alleles in any gene is often concentrated on a small number of low-…
An efficient multi-locus mixed-model approach for genome-wide association studies in structured populations
Population structure causes genome-wide linkage disequilibrium between unlinked loci,
leading to statistical confounding in genome-wide association studies. Mixed models have …
leading to statistical confounding in genome-wide association studies. Mixed models have …
Sustainable university: what can be the matter?
L Velazquez, N Munguia, A Platt, J Taddei - Journal of cleaner production, 2006 - Elsevier
This article presents a comprehensive managerial model for a sustainable university
created by D.Sc. L. Velazquez with empirical data collected from about 80 higher education …
created by D.Sc. L. Velazquez with empirical data collected from about 80 higher education …
[HTML][HTML] Rare variant contribution to human disease in 281,104 UK Biobank exomes
Genome-wide association studies have uncovered thousands of common variants associated
with human disease, but the contribution of rare variants to common disease remains …
with human disease, but the contribution of rare variants to common disease remains …