[HTML][HTML] Autotaxin: structure-function and signaling
A Perrakis, WH Moolenaar - Journal of lipid research, 2014 - ASBMB
Autotaxin (ATX), or ecto-nucleotide pyrophosphatase/phosphodiesterase-2, is a secreted
lysophospholipase D (lysoPLD) that hydrolyzes extracellular lysophospholipids into the lipid …
lysophospholipase D (lysoPLD) that hydrolyzes extracellular lysophospholipids into the lipid …
[HTML][HTML] Structure and function of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family: Tidying up diversity
Ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family members (ENPP1–7)
have been implicated in key biological and pathophysiological processes, including …
have been implicated in key biological and pathophysiological processes, including …
Automated protein model building combined with iterative structure refinement
A Perrakis, R Morris, VS Lamzin - Nature structural biology, 1999 - nature.com
In protein crystallography, much time and effort are often required to trace an initial model
from an interpretable electron density map and to refine it until it best agrees with the …
from an interpretable electron density map and to refine it until it best agrees with the …
Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7
G Langer, SX Cohen, VS Lamzin, A Perrakis - Nature protocols, 2008 - nature.com
ARP/wARP is a software suite to build macromolecular models in X-ray crystallography
electron density maps. Structural genomics initiatives and the study of complex macromolecular …
electron density maps. Structural genomics initiatives and the study of complex macromolecular …
Small is beautiful: protein micro-crystallography
…, H Belrhali, A Bram, M Burghammer, A Perrakis… - Nature Structural …, 1998 - nature.com
Focused X-ray beams from third generation synchrotron sources allow the possibility of data
collection from previously unusable protein microcrystals of only a few microns in size.
collection from previously unusable protein microcrystals of only a few microns in size.
[HTML][HTML] RNA-binding protein Dnd1 inhibits microRNA access to target mRNA
MicroRNAs (miRNAs) are inhibitors of gene expression capable of controlling processes in
normal development and cancer. In mammals, miRNAs use a seed sequence of 6–8 …
normal development and cancer. In mammals, miRNAs use a seed sequence of 6–8 …
[PDF][PDF] Complete mesocolic excision with central vascular ligation produces an oncologically superior specimen compared with standard surgery for carcinoma of the …
Purpose The plane of surgery in colonic cancer has been linked to patient outcome although
the optimal extent of mesenteric resection is still unclear. Surgeons in Erlangen, Germany, …
the optimal extent of mesenteric resection is still unclear. Surgeons in Erlangen, Germany, …
[HTML][HTML] AlphaFill: enriching AlphaFold models with ligands and cofactors
Artificial intelligence-based protein structure prediction approaches have had a transformative
effect on biomolecular sciences. The predicted protein models in the AlphaFold protein …
effect on biomolecular sciences. The predicted protein models in the AlphaFold protein …
[HTML][HTML] The PDB_REDO server for macromolecular structure model optimization
The refinement and validation of a crystallographic structure model is the last step before
the coordinates and the associated data are submitted to the Protein Data Bank (PDB). The …
the coordinates and the associated data are submitted to the Protein Data Bank (PDB). The …
[HTML][HTML] Developments in the CCP4 molecular-graphics project
…, GN Murshudov, S Cohen, A Perrakis… - … Section D: Biological …, 2004 - scripts.iucr.org
Progress towards structure determination that is both high-throughput and high-value is
dependent on the development of integrated and automatic tools for electron-density map …
dependent on the development of integrated and automatic tools for electron-density map …