Peroxiredoxins (Prxs) are a ubiquitous family of cysteine-dependent peroxidase enzymes
that play dominant roles in regulating peroxide levels within cells. These enzymes, often …

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, commonly referred to as
statins, are widely used in the treatment of dyslipidaemia, in addition to providing primary and …

Numerous examples exist of how disrupting the actions of physiological regulators of blood
cell development yields hematologic malignancies. The master regulator of hematopoietic …

Newborn mice homozygous for a targeted disruption of insulin-like growth factor gene 1 (Igf-1)
exhibit a growth deficiency similar in severity to that prevlously observed in viable Igf-2 …

The intensification and expansion of modern agriculture is amongst the greatest current
threats to worldwide biodiversity. Over the last quarter of the 20th century, dramatic declines in …

We developed a massive-scale RNA sequencing protocol, short quantitative random RNA
libraries or SQRL, to survey the complexity, dynamics and sequence content of transcriptomes …

Objective. To design a brief cognitive screener with acceptable sensitivity and specificity for
identifying subjects with cognitive impairment Design. Cohort one is assembled from a …

Background: Although effective treatment of depressed patients requires regular follow-up
contacts and symptom monitoring, an efficient method for assessing treatment outcome is …

Extending and improving an earlier work of the second author, an Integer Programming (IP)
model is developed to minimize the operating and lay-up costs for a fleet of liner ships …

XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas.
Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed …