User profiles for A. Okbay

Aysu Okbay

Vrije Universiteit Amsterdam
Verified email at vu.nl
Cited by 8592

Genome-wide association study identifies 74 loci associated with educational attainment

A Okbay, JP Beauchamp, MA Fontana, JJ Lee, TH Pers… - Nature, 2016 - nature.com
Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …

[HTML][HTML] Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

A Okbay, Y Wu, N Wang, H Jayashankar, M Bennett… - Nature …, 2022 - nature.com
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome-wide-…

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

A Okbay, BML Baselmans, JE De Neve, P Turley… - Nature …, 2016 - nature.com
Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a phenotype …

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

…, AR Hammerschlag, MG Nivard, A Okbay… - Nature …, 2019 - nature.com
Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …

Multi-trait analysis of genome-wide association summary statistics using MTAG

P Turley, RK Walters, O Maghzian, A Okbay, JJ Lee… - Nature …, 2018 - nature.com
We introduce multi-trait analysis of GWAS (MTAG), a method for joint analysis of summary
statistics from genome-wide association studies (GWAS) of different traits, possibly from …

Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

…, E Krapohl, E Taskesen, AR Hammerschlag, A Okbay… - Nature …, 2017 - nature.com
Intelligence is associated with important economic and health-related life outcomes 1.
Despite intelligence having substantial heritability 2 (0.54) and a confirmed polygenic nature, …

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

…, J Grove, KE Samocha, JI Goldstein, A Okbay… - Nature …, 2017 - nature.com
Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation.
We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of …

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

JJ Lee, R Wedow, A Okbay, E Kong, O Maghzian… - Nature …, 2018 - nature.com
Here we conducted a large-scale genetic association analysis of educational attainment in
a sample of approximately 1.1 million individuals and identify 1,271 independent genome-…

[HTML][HTML] Mendelian imputation of parental genotypes improves estimates of direct genetic effects

AI Young, SM Nehzati, S Benonisdottir, A Okbay… - Nature Genetics, 2022 - nature.com
Abstract Effects estimated by genome-wide association studies (GWASs) include effects of
alleles in an individual on that individual (direct genetic effects), indirect genetic effects (for …

Resource profile and user guide of the Polygenic Index Repository

…, D Cesarini, DJ Benjamin, P Turley, A Okbay - Nature human …, 2021 - nature.com
Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many
scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent …