We present an individualized systems medicine (ISM) approach to optimize cancer drug
therapies one patient at a time. ISM is based on (i) molecular profiling and ex vivo drug …

Background The autoimmune regulator (AIRE) gene influences thymic self-tolerance induction.
In autoimmune polyendocrinopathy syndrome type 1 (APS1; OMIM 240300), recessive …

Background Until recently, chromosomal translocations and fusion genes have been an
underappreciated class of mutations in solid tumors. Next-generation sequencing technologies …

Purpose: Response to standard oncologic treatment is limited in colorectal cancer. The
gene expression–based consensus molecular subtypes (CMS) provide a new paradigm for …

FusionCatcher is a software tool for finding somatic fusion genes in paired-end RNA-sequencing
data from human or other vertebrates. FusionCatcher achieves competitive detection …

Neutralizing autoantibodies to type I, but not type II, interferons (IFNs) are found at high titers
in almost every patient with autoimmune polyendocrinopathy candidiasis ectodermal …

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR receptor
family consisting of two closely related type I transmembrane proteins ROR1 and ROR2. …

1. A cornerstone concept of ecological immunology is that immune function, interacting with
various aspects of individual health state, plays a central role in the life‐history trade‐offs …

We developed a systematic algorithmic solution for quantitative drug sensitivity scoring (DSS),
based on continuous modeling and integration of multiple dose-response relationships in …

RNA-sequencing and tailored bioinformatic methodologies have paved the way for identification
of expressed fusion genes from the chaotic genomes of solid tumors. We have recently …